m^(6)A甲基化修饰在动脉粥样硬化中的作用

The role of m^(6)A methylation modification in atherosclerosis

N6-甲基嘌呤(m^(6)A)是真核生物中最常见的转录后RNA修饰类型,涉及多种类型RNA。m^(6)A甲基化修饰是动态可逆的,主要由多种酶和蛋白进行调控,包括甲基转移酶、去甲基化酶和m^(6)A相关结合蛋白。动脉粥样硬化是心脑血管疾病的主要原因。近期研究发现m^(6)A甲基化修饰与动脉粥样硬化密切相关。该文总结了目前对m^(6)A甲基化修饰机制的认识,并阐述了与动脉粥样硬化相关细胞中m^(6)A甲基化修饰的机制及最新进展,为动脉粥样硬化的诊断和防治提供新靶点。

N6-methylpurine(m^(6)A)is the most common type of post-transcriptional RNA modification in eukaryotes,involving many types of RNA.m^(6)A methylation modification is dynamic and reversible and is mainly regulated by a variety of enzymes and proteins,including methyltransferase,demethylase and m^(6)A-related binding proteins.Atherosclerosis is the main cause of cardiovascular and cerebrovascular diseases.Recent studies have found that m^(6)A methylation is closely related to atherosclerosis.This paper summarizes the current understanding of the mechanism of m^(6)A methylation modification,and reviews the mechanism and latest progress of m^(6)A methylation modification in atherosclerosis-related cells,so as to provide a new target for the diagnosis,prevention and treatment of atherosclerosis.