基于中医瘀血理论探讨干燥综合征的发病机制及治疗

Discussion on Pathogenesis and Treatment Progress of Sjogren’s Syndrome Based on Blood Stasis Theory of Traditional Chinese Medicine

干燥综合征(Sjogren’s syndrome,SS)是一种慢性自身免疫性疾病,以免疫细胞浸润、唾液腺和泪腺进行性损伤为主要特征,除了影响泪腺和唾液腺,导致眼睛干涩和口干症状外,还会累及人体皮肤关节、肺、肾和消化、神经及血液等多个系统,严重影响人体身心健康。近年来西医在该病的诊断和治疗方面有了广泛和深入的研究,但目前还没有针对潜在病因的治疗方法。古往今来,众多医家从滋阴润燥、养阴生津方面论治本病取得了一定的疗效。近年来随着研究的进一步深入,很多学者发现本病与瘀血密切相关,活血化瘀法也被证实在治疗本病方面疗效确切。瘀血既是病理产物,同时也是致病因素,本病很多的病理变化都与此相关。本文拟从炎症-细胞因子-凝血系统、血管生成及冷球蛋白血症等方面论述瘀血与本病的相关性,并进一步论证活血化瘀法的临床疗效,以期为后期的研究提供理论依据。

Sjogren’s Syndrome is a chronic autoimmune disease. It is mainly characterized by immune cell infiltration and progressive damage to salivary and lacrimal glands. In addition to affecting lacrimal and salivary glands, resulting in dry eyes and dry mouth, SJ?gren’s syndrome(SS) also involves many systems of human skin, joints, lungs, kidneys,digestion, nerves and blood, seriously affecting human physical and mental health. In recent years, western medicine has made extensive and in depth research in the diagnosis and treatment of this disease, but there is no treatment for the underlying cause. Since ancient times, many doctors have achieved certain curative effects in the treatment of t-his disease from the aspects of Nourishing Yin, moistening dryness, nourishingy in and generating fluid. In recent years, with the further research, many scholars have found that the disease is closely related to blood stasis, and the met-hod of promoting blood circulation and removing blood stasis has also been proven to be effective in treating the disease. Blood stasis is both a pathological product and a pathogenic factor. Many pathological changes of this disease are related to this. This paper intends to discuss the correlation between blood stasis and this disease from the aspects of inflammation cytokine coagulation system, angiogenesis and cryoglobulinemia, and further demonstrate the clinical efficacy of the method of activating blood circulation and removing blood stasis, so as to provide theoretical basis for the later experimental and clinical research of this disease.