基于免疫机制从“脾虚生痰湿”论治多发性抽动症的研究

Study on the Treatment of Tourette Syndrome Based on Immune Mechanism From "Spleen Deficiency Produces Phlegm and Dampness"

多发性抽动症的发病率逐年升高,严重影响儿童生长发育及心理健康。中医治疗多发性抽动症(脾虚痰湿型)取得显著效果,但作用机制仍不明确。近年来,诸多研究表明“脾虚生痰湿”和免疫系统之间存在密切关系,还揭示了免疫机制在抽动症发病中起重要作用。本文通过概述多发性抽动症(脾虚痰湿型)的病机与免疫之间的关系,发现多发性抽动症(脾虚痰湿型)患者免疫状态与大脑皮质-基底节-丘脑-皮层回路异常密切相关,细胞免疫损伤参与了多发性抽动症的发生和发展。并分析了健脾化痰祛湿中药治疗多发性抽动症的潜在机制,为从“脾虚生痰湿”论治多发性抽动症提供相关科学依据。

The incidence of tourette syndrome is increasing year by year, which seriously affects the growth and mental health of children. Chinese medicine treatment of tourette syndrome(splenic asthenia and phlegm-damp type) has achieved remarkable results, but the mechanism of action is still unclear. In recent years, many studies have shown that there is a close relationship between spleen deficiency and phlegm-dampness and immune system, and also revealed that immune mechanism plays an important role in the onset of tic syndrome. This paper summarizes the relationship between the pathogenesis and immunity of tourette syndrome(splenic asthenia and phlegm-damp type), and finds that the immune state of tourette syndrome(splenic asthenia and phlegm-damp type) is closely related to the abnormal cortical-basal-thalamic-cortical circuit, and the cellular immune damage is involved in the occurrence and development of tourette syndrome. The potential mechanism of treating tourette syndrome with traditional Chinese medicine of invigorating spleen, resolving phlegm and removing dampness was analyzed, which provided relevant scientific basis for treating tourette syndrome with "spleen deficiency producing phlegm and dampness".