Co-opting signalling molecules enables logic-gated control of CAR T cells

Although chimeric antigen receptor(CAR)T cells have altered the treatment landscape for B cell malignancies,the risk of on-target,off-tumour toxicity has hampered their development for solid tumours because most target antigens are shared with normal cells1,2.Researchers have attempted to apply Boolean-logic gating to CAR T cells to prevent toxicity3-5;however,a truly safe and effective logic-gated CAR has remained elusive6.