上海市松江区健康体检人群肿瘤标记物水平分析

The analysis of tumor markers in healthy physical population in Songjiang district of Shanghai

目的研究上海市松江区健康体检人群的肿瘤标记物(TM)水平及其应用价值。方法选取2021年1月至12月到上海市松江区中心医院体检中心进行健康体检的37695例体检者为研究对象进行回顾性分析,分析不同TM的检测水平及其异常检出率,比较不同性别、不同年龄体检人群的TM水平。结果检测结果显示,所有TM中细胞角蛋白19片段(CY211)异常检出率最高,男性癌胚抗原(CEA)和CY211异常率明显高于女性(P<0.05),而女性糖类抗原199(CA199)异常率高于男性(P<0.05),不同性别人群中甲胎蛋白(AFP)异常检出率比较,差异无统计学意义(P>0.05)。AFP、CEA、CA199、CY211均在61岁以上年龄组体检者中异常检出率最高,男性人群总前列腺特异性抗原(TPSA)、游离前列腺特异性抗原(FPSA)及女性人群糖类抗原153(CA153)也是在61岁以上年龄组体检者中异常检出率最高。CEA和男性TPSA异常检出率随年龄增加而升高。女性糖类抗原125(CA125)在31~40岁的年龄组异常检出率最高。结论不同性别、不同年龄的体检人群TM水平比较,差异有统计学意义,联合检测多项TM有利于疾病的早发现早治疗。

Objective To study the level and application value of tumor marker(TM)in healthy population in Songjiang district of Shanghai.Methods A total of 37695 healthy people from Songjiang District who have done physical examination in the physical examination center of Shanghai Songjiang District Central Hospital from January 2021 to December 2021 were included in this study.This study was a retrospective data analysis.Different TM detection levels and abnormal detection rates were analyzed,and the TM levels of people with different genders and different ages were compared.Results The results showed that the abnormal detection rate of cytokeratin 19 fragment(CY211)in all TM was the highest,and the abnormal rate of carcinoembryonic antigen(CEA)and CY211 in males was significantly higher than that in females(P<0.05),while the abnormal detection rate of carbohydrate antigen 199(CA199)in females was higher than that in males(P<0.05).There was no significant difference in the abnormal detection rate of alpha fetoprotein(AFP)in different gender groups(P>0.05).The abnormal detection rates of AFP,CEA,CA199 and CY211 were the highest in the age group over 61 years.The abnormal detection rates of total prostate specific antigen(TPSA),free prostate specific antigen(FPSA)and carbohydrate antigen 153(CA153)in the male population were also the highest in the age group over 61 years.The abnormal detection rates of CEA and male TPSA increased with age.The abnormal detection rate of carbohydrate antigen 125(CA125)in female population was the highest in the age group of 31~40.Conclusion There are significant differences in the levels of TM among different gender and age groups.Combined detection of multiple TM is beneficial to early detection and treatment of the disease.