“补气生血法”促肝切除术后肝再生理论初探

Preliminary Theoretical Research of Facilitative Effect on Liver Regeneration after Hepatectomy by Treatment of Invigorating Qi and Regenerating Blood

肝切除术是治疗肝脏多种良、恶性疾病的主要手段,但术后病死率居高不下,究其原因则主要归结于肝再生的不足。本文结合中医气血理论、藏象学说及肝切除术后肝再生的现代研究进展,分析肝切除与肝再生的中医内涵,并从肝脏本身的特点及再生能量供给两方面阐述肝再生机制与气血理论之间的关系,提出“气血亏虚”是肝切除术后肝再生不足的重要病机,认为以当归补血汤为代表的“补气生血法”可使肝体充盈、肝气条畅,有效促进肝再生,旨在探索传统理论及经典方药在肝再生领域的应用,为降低肝切除术后病死率提供中医治疗思路。

Hepatectomy is a main approach for the treatment of various benign and malignant diseases of the liver;however,the postoperative mortality remains high in term of the insufficient liver regeneration.Based on the theory of Qi and Blood,the theory of Visceral Manifestations in TCM,and advances in modern research,the TCM connotation of hepatic resection and Liver regeneration is analyzed,and the relationship between Liver regeneration mechanisms and the theory of Qi and Blood is explained from both the characteristics of the Liver and the supply of regenerative energy.Meanwhile,we propose that“deficiency of Qi and Blood”is an important pathogenic mechanism of insufficient liver regeneration after hepatectomy,and the treatment of“invigorating Qi and generating Blood”represented by Danggui Buxue Decoction can effectively promote Liver regeneration by keeping Qi filled and unobstructed in Liver.This may contribute to explore the application of traditional theories and classical prescriptions in Liver regeneration and provide a useful TCM strategy for reducing the mortality rate after hepatectomy.