益气化瘀通络方联合常规西药治疗气虚血瘀型冠心病介入术后患者的效果

Effects of Yiqi Huayu Tongluo prescription combined with conventional western medicine in treatment of patients with coronary heart disease of qi deficiency and blood stasis type after interventional therapy

目的:观察益气化瘀通络方联合常规西药治疗气虚血瘀型冠心病介入术后患者的效果。方法:选取2020年5月至2022年1月该院收治的100例气虚血瘀型冠心病介入术后患者进行前瞻性研究,采用随机数字表法将其分为对照组和研究组各50例。对照组术后给予常规西药治疗,研究组在对照组基础上采用益气化瘀通络方治疗,比较两组治疗前后中医证候积分、治疗后6个月终点事件发生率、血脂指标[血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平和心功能指标[每搏输出量(SV)、左心房内径(LAD)、左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)]水平。结果:治疗后,研究组心悸、胸痛、神疲乏力和气短等中医证候积分均低于对照组,差异有统计学意义(P<0.05);研究组终点事件发生率为6.00%(3/50),低于对照组的26.00%(13/50),差异有统计学意义(P<0.05);治疗后,研究组HDL-C、SV、LVEF水平均高于对照组,TG、LDL-C、TC、LAD、LVESD、LVEDD水平均低于对照组,差异有统计学意义(P<0.05)。结论:在常规西药治疗基础上采用益气化瘀通络方治疗气虚血瘀型冠心病介入术后患者可降低中医证候积分和终点事件发生率,改善血脂指标和心功能指标水平,效果优于单纯常规西药治疗。

Objective:To observe effects of Yiqi Huayu Tongluo prescription combined with conventional western medicine in treatment of patients with coronary heart disease of qi deficiency and blood stasis type after interventional therapy.Methods:A prospective study was conducted on 100 patients with coronary heart disease of qi deficiency and blood stasis type after interventional therapy admitted to this hospital from May 2020 to January 2022.They were divided into control group and study group by using the random number table method,50 cases in each group.The control group was treated with conventional western medicine after the surgery,while the study group was treated with Yiqi Huayu Tongluo Prescription on the basis of that of the control group.The TCM syndrome scores before and after the treatment,the incidence of endpoint events 6 months after the treatment,the levels of blood lipid indexes[serum triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],and the cardiac function index levels[stroke volume(SV),left atrial diameter(LAD),left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)]were compared between the two groups.Results:After the treatment,the scores of TCM syndromes such as palpitation,chest pain,fatigue and shortness of breath in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of endpoint events in the study group was 6.00%(3/50),which was lower than 26.00%(13/50)in the control group,and the difference was statistically significant(P<0.05).Further,after the treatment,the levels of HDL-C,SV and LVEF in the study group were higher than those in the control group,the levels of TG,LDL-C,TC,LAD,LVESD and LVEDD were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:On the basis of the conventional western medicine treatment,Yiqi Huayu Tongluo prescription can reduce the scores of TCM syndromes and the incidence of endpoint events,and improve the levels of blood lipid indexes and cardiac function indexes in the patients with coronary heart disease of qi deficiency and blood stasis type after interventional therapy.Moreover,it is superior to single conventional western medicine treatment.