柴芩承气汤加减联合西药治疗急性胰腺炎的临床疗效分析

Clinical efficacy of modified Chaiqin Chengqi Decoction combined with Western medicine in the treatment of acute pancreatitis

目的探究柴芩承气汤加减联合西药治疗急性胰腺炎的临床疗效。方法104例急性胰腺炎患者,按照随机数字表法分为对照组和研究组,各52例。对照组采用西药治疗,研究组在对照组基础上联合使用柴芩承气汤加减治疗。对比两组治疗前后白细胞计数(WBC)、C反应蛋白(CRP)、淀粉酶(AMS)水平,治疗效果,治疗前后生活质量评分,不良反应发生情况。结果治疗后,研究组WBC(6.36±2.29)×10^(9)/L、CRP(6.96±5.35)mg/L、AMS(152.63±32.61)U/L均低于对照组的(10.52±1.36)×10^(9)/L、(9.63±2.22)mg/L、(241.63±7.19)U/L,差异均有统计学意义(P<0.05)。研究组治疗总有效率94.23%高于对照组的80.77%,差异有统计学意义(P<0.05)。治疗后,研究组生理机能、生理职能、社会功能和精神状态评分分别为(80.63±2.38)、(85.63±10.32)、(79.63±17.63)、(82.63±2.95)分,均高于对照组的(71.37±9.49)、(68.93±10.16)、(70.64±19.19)、(70.57±4.24)分,差异均有统计学意义(P<0.05)。研究组不良反应发生率3.85%低于对照组的17.31%,差异有统计学意义(P<0.05)。结论柴芩承气汤加减联合西药治疗急性胰腺炎疗效好,患者用药后WBC、CRP、AMS水平均有显著改善,不良反应少,值得临床推广。

Objective To investigate the clinical efficacy of modified Chaiqin Chengqi Decoction combined with Western medicine in the treatment of acute pancreatitis.Methods A total of 104 patients with acute pancreatitis were divided into control group and research group according to the random numerical table,with 52 cases in each group.The control group was treated with Western medicine,and the research group was treated with modified Chaiqin Chengqi Decoction on the basis of the control group.Both groups were compared in terms of levels of white blood cell count(WBC),C-reactive protein(CRP),α-amylase(AMS),therapeutic effects,quality of life score before and after the treatment,and the occurrence of adverse reactions.Results After the treatment,the WBC(6.36±2.29)×10^(9)/L,CRP(6.96±5.35)mg/L,and AMS(152.63±32.61)U/L in the research group were lower than(10.52±1.36)×10^(9)/L,(9.63±2.22)mg/L,and(241.63±7.19)U/L in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the research group was 94.23%,which was higher than 80.77%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the physiological function,physical function,social function and mental status scores of the research group were(80.63±2.38),(85.63±10.32),(79.63±17.63),and(82.63±2.95)points,which were higher than(71.37±9.49),(68.93±10.16),(70.64±19.19),and(70.57±4.24)points of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the research group was 3.85%,which was lower than 17.31%in the control group,and the difference was statistically significant(P<0.05).Conclusion Modified Chaiqin Chengqi Decoction combined with Western medicine has good efficacy in the treatment of acute pancreatitis,and the levels of WBC,CRP and AMS have been significantly improved after treatment,with few adverse reactions,which is worthy of clinical promotion.