摘要
肝豆状核变性是一种常染色体隐性遗传病,临床表现差异很大,育龄期女性多表现为月经不规律甚至闭经,未经系统治疗者很难怀孕,即便怀孕也容易流产。现就肝豆状核变性患者孕期用药问题展开综述,同时也讨论分娩方式、麻醉药物的选择以及母乳喂养安全性等问题。
Hepatolenticular degeneration(HLD)is an autosomal recessive genetic disease with a wide range of clinical manifestations.Women of childbearing age often present with irregular or even absent menstruation.Getting pregnant can be difficult without systematic treatment,and even if someone does become pregnant,miscarriages are common.This article reviews the use of medication during pregnancy in patients with hepatolenticular degeneration and also discusses the mode of delivery,anesthetic drug selection,and breastfeeding safety.
作者
肖倩倩
范建高
Xiao Qianqian;Fan Jiangao(Department of Gastroenterology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai Key Lab of Pediatric Gastroenterology and Nutrition,Shanghai 200092,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2022年第11期1276-1279,共4页
Chinese Journal of Hepatology
基金
国家自然科学基金资助项目(81873565,81470840)
国家重点研发计划(2021YFC2700802)
上海市领军人才培养计划项目(2017019)
上海交通大学医学院高水平地方高校创新团队课题(2018)
上海交通大学医学院附属新华医院临床研究培育基金项目(2017CSK04)。
关键词
肝豆状核变性
妊娠
药物疗法
麻醉
母乳喂养
Wilson disease
Pregnancy
Drug therapy
Anesthesia
Breast feeding
