2016—2022年基于UK Biobank数据库的心血管疾病研究热点的可视化分析

Visual analysis of research hotspots of cardiovascular diseases based on UK Biobank database from 2016 to 2022

目的分析基于英国生物样本数据库(UK Biobank)开展的关于心血管疾病的研究热点和发展趋势,为研究者开展心血管疾病相关研究提供科学参考。方法在Web of Science核心集数据库中检索2016年至2022年期间基于UK Biobank数据库开展的关于心血管疾病研究的文献,运用Citespace 6.1.R 2和VOSviewer 1.6.18软件分别从国家、机构、关键词等方面对心血管疾病的研究热点和发展趋势进行可视化分析。结果研究共纳入284篇文献,整体发文量处于增长趋势;发文量排在第1位的作者是S.PETERSEN,发文量最多的国家是英国,发文量最多的机构是英国牛津大学;关键词突现分析提示,近5年研究趋势主要集中在危险因素分析(adiposity,body mass index)、全基因组关联研究(genome-wide association study)与疾病预后分析(therapy,all-cause mortality)等方面的研究。另外,以“smoking”为代表的危险因素探讨、基因表达(loci,expression)和以孟德尔随机化为代表的偏倚控制方法探讨(Mendelian randomization,bias)是现阶段基于UK Biobank数据库开展的有关脑血管疾病的研究热点。结论当前基于UK Biobank数据库的心血管疾病研究处于快速发展期,英国与美国在该领域开展的研究较多,近5年该领域研究趋势和热点主要集中在心血管疾病的危险因素分析、基因表达、疾病预后分析与偏倚控制方法等方面。

Objective To analyze the research hotspots and development trends of cardiovascular diseases based on UK Biobank database from 2016 to 2022,and to provide scientific reference for researchers to carry out research on cardiovascular diseases.Methods The literatures on cardiovascular disease research based on UK Biobank database were retrieved from 2016 to 2022 in the Web of Science core set database in our study.Citespace 6.1.R 2 and VOSviewer 1.6.18 software were used to visually analyze the research hotspots and development trends of cardiovascular diseases from countries,institutions,keywords,etc.Results Two hundred and eighty-four literatures were included in this study and the overall number of publications was on the rise.The author with the highest number of publications was S.PETERSEN.The country with the largest number of publications was the UK,keyword emergence analysis indicated that the research trend in recent 5 years mainly focused on risk factor analysis(“adiposity”“body mass index”),genome-wide association study,and disease prognosis analysis(“therapy”“all-cause mortality”).In addition,the research on risk factors such as smoking,gene expression and bias control methods such as Mendelian randomization were hot spots of research on cerebrovascular diseases based on the UK Biobank database at this stage.Conclusion At present,cardiovascular disease research based on the UK Biobank database is in a rapid development period.There are many researches in this field in UK and in the United States.In recent five years,research trends and hotspots in this field mainly focus on risk factor analysis,gene expression,disease prognosis analysis and bias control methods of cardiovascular diseases.