妊娠期危险因素与子代发生特应性皮炎的关系研究进展

Research progress on the effects of pregnancy-related risk factors for atopic dermatitis in the offspring

近年来婴幼儿特应性皮炎患病率呈上升趋势,研究表明孕妇在妊娠期间常受环境、饮食等影响并发各种疾病,相关危险因素同时会透过胎盘作用于胎儿,诱导新生儿体内Th1/Th2失衡、肠道菌群紊乱等,影响子代特应性皮炎的发生。本文从环境因素、饮食因素、精神因素、分娩方式、妊娠期过敏等方面综述相关危险因素对子代特应性皮炎影响的研究进展,以期为孕妇提供指导,降低子代患病风险。

In recent years,the prevalence of atopic dermatitis in infants and young children has been on the rise.Studies have shown that pregnant women are often affected by environment,diet and other factors during pregnancy and complicated with various diseases.The pregnancy-related risk factors can affect the fetus through the placenta,causing Th1/Th2 imbalance and intestinal flora disorder in newborn,thereby affecting the development of atopic dermatitis in offspring.This article reviews the progress of research on the effects of risk factors,including environmental factors,dietary factors,psychological factors,mode of delivery,and allergies during pregnancy,on atopic dermatitis in the offspring,in order to provide guidance to pregnant women and to reduce the risk of diseases in the offspring.