结直肠癌肝转移预测及预后的影像组学综述

Radiomics Review on Prediction and Prognosis of Liver Metastasis in Colorectal Cancer

结直肠癌在国内外都是高发病率和高死亡率的肿瘤疾病,肝脏是结直肠癌血行转移最主要的靶器官,尽早准确地预测结直肠癌肝转移的发生以及监测患者治疗的预后反应,对患者的诊断和治疗尤为关键。新兴的影像组学为精准预测结直肠癌肝转移以及评估预后提供新的可能。对现有的结直肠癌肝转移影像组学研究进行综述,首先介绍结直肠癌肝转移研究的临床意义以及现有研究存在的缺陷,然后阐述结直肠癌肝转移影像组学的分析流程,接着对结直肠癌肝转移影像组学的4个研究方向展开综述,包括肝转移病理生长模式预测、隐匿性肝转移预测、肝转移疗效预后评估、肝转移患者生存期预后评估;阐明各个方向的最新研究进展及存在的缺陷性;最后对结直肠癌肝转移影像组学的未来发展趋势进行展望。

Colorectal cancer is a cancer disease with high morbidity and mortality at home and abroad.Liver is a main target organ for colorectal cancer metastases.Predicting the occurrence of liver metastasis of colorectal cancer and real-time monitoring the prognostic response of patients is particularly critical to the diagnosis and treatment of the patients.Emerging radiomics offers possibilities for the accurate prediction of liver metastases and prognosis of colorectal cancer.In this paper,existing radiomics studies on colorectal cancer liver metastases(CRLM)were reviewed.Firstly,the clinical significance of CRLM and the limitations of the existing studies were introduced.Secondly,the radiomics analysis process of CRLM was described.Then,four research directions of radiomics on CRLM were reviewed,including predicting the histopathologic growth patterns(HGPs)in CRLM,predicting the hidden liver metastasis,prognosis assessment of liver metastases,and predicting the prognosis of survival in patients with liver metastasis.The latest research progress and challenges in each of the directions were described in detail.Finally,the future development trend of liver metastases radiomics of colorectal cancer was prospected.