绿茶提取物可致特异质型肝损伤?——与美国最新版药物性肝损伤指南商榷

Can green tea extract cause specific liver injury?——Discussion of the latest US guidelines on drug-induced liver injury

近年来,绿茶提取物的潜在肝毒性越来越多的引起了人们的关注。本文通过现有绿茶提取物肝损伤相关研究,结合最新药物肝毒性分类,对其肝损伤的客观性和成因机制进行了系统的阐述和分析。进一步根据绿茶提取物致肝损伤的主要风险因素,提出了安全合理使用此类产品的相关建议,以期为绿茶提取物肝损伤机制的深入研究和风险的防控提供有价值的见解,同时,也为绿茶提取物改善健康状况的治疗性使用提供重要的参考。

In recent years, the potential hepatotoxicity of green tea extract(GTE) has attracted more and more attention. With reference to the current studies on liver injury caused by GTE and the latest drug hepatotoxicity classification, this article systematically elaborates on the objectivity and causal mechanisms of liver injury caused by GTE. Based on the main risk factors for liver injury caused by GTE, this article also proposes recommendations for safe and rational use of such products, so as to provide valuable insights for in-depth research on the mechanism of liver injury caused by GTE and risk prevention and control, and meanwhile, it also provides an important reference for the therapeutic use of GTE to improve health conditions.