肝硬化患者肌肉减少症与肝性脑病的关系

Research advances in the association between sarcopenia and hepatic encephalopathy in patients with liver cirrhosis

肌肉减少症(简称肌少症)是肝硬化患者营养不良的表现形式之一。大多数研究表明,肌少症与显性肝性脑病导致肝硬化患者生活质量下降、临床预后不良甚至死亡等事件风险增加,但关于肌少症与轻微性肝性脑病之间的关系研究不多。通过对肌少症与肝性脑病的相关研究进展进行综述,指出改善患者的营养状况可预防轻微性肝性脑病发生,甚至降低显性肝性脑病的发生,从而改善患者预后,提高生存质量,降低死亡风险。

Sarcopenia is one of the manifestations of malnutrition in patients with liver cirrhosis.Most studies have shown that sarcopenia is associated with overt hepatic encephalopathy(OHE),leading to an increased risk of events such as reduced quality of life,poor clinical prognosis,and even death in patients with liver cirrhosis,but there are few studies on the association between sarcopenia and minimal hepatic encephalopathy(MHE).This article reviews the research advances in sarcopenia and hepatic encephalopathy to provide a reliable basis for clinical treatment,and it is pointed out that the nutritional status of patients can be improved to prevent MHE and even reduce the onset of OHE,thereby improving patient prognosis,increasing quality of life,and reducing the risk of death.