脂代谢紊乱在炎症性皮肤病中的作用及相关药物研究进展

Research progress in roles of lipid metabolism disorders in inflammatory dermatoses and in related drugs

炎症性皮肤病是免疫系统失调导致皮肤屏障破坏的一类疾病,包括银屑病、特应性皮炎和Netherton综合征等。炎症性皮肤病患者血脂水平与炎症因子水平密切相关,两者共同参与疾病的发生发展。皮肤脂质分泌异常导致皮肤屏障功能受损,高水平炎症因子导致血脂水平异常,并影响脂代谢相关酶表达,进一步加重皮肤炎症。脂代谢调控转录因子过氧化物酶体增殖物激活受体和肝X受体可调控脂代谢和炎症信号通路,进而改善皮肤屏障功能。本文综述脂代谢紊乱在炎症性皮肤病的作用,并对目前炎症性皮肤病治疗药物予以汇总和展望。

Inflammatory dermatoses are a group of diseases in which dysregulation of the immune system leads to disruption of the skin barrier,including psoriasis,atopic dermatitis,and Netherton syn⁃drome.In patients with inflammatory dermatoses,the level of lipids is closely related to the level of inflammatory factors,both of which are jointly involved in the development of the disease.Abnormal skin lipid secretion leads to impaired skin barrier function,while high levels of inflammatory factors lead to abnormal blood lipid levels and affect the expression of enzymes related to lipid metabolism and further aggravate skin inflammation.Peroxisome proliferators-activated receptors and liver X receptors improve skin barrier function by regulating lipid metabolism and inflammatory signaling pathways.In this paper,the role of lipid metabolism disorders in inflammatory dermatoses was analyzed,and the current therapeutic agents for inflammatory dermatoses were summarized.