抗MDA5抗体与皮肌炎相关性研究进展

Update of the relationship between anti melanoma differentiation related gene 5 antibody and dermatomyolsitis

抗黑素瘤分化相关基因5(MDA5)抗体是一种发现于皮肌炎(DM)的肌炎特异性抗体。抗MDA5抗体与临床无肌病性皮肌炎(CADM)和急进型间质性肺病变(RP-ILD)密切相关,增加了出现几种特征性皮肤表现的风险,包括Gottron征/丘疹、披肩征、脂膜炎等,降低了肌肉无力、典型皮肌炎(CDM)和肌酸激酶升高的风险。抗MDA5抗体与疾病的进展、预后有密切关系。本研究将对抗MDA5抗体与DM相关临床表现的相关性进行综述。

Anti melanoma differentiation related gene 5(MDA5)antibody is a myositis specific antibody found in dermatomyositis(DM).Anti MDA5 antibody is closely related to clinical amyotrophic dermatomyositis(CADM)and rapidly progressive interstitial lung disease(RP-ILD),which increases the risk of several characteristic skin manifestations,including gottron syndrome/papule,shawl sign,panniculitis,and reduces the risk of muscle weakness,typical dermatomyositis(CDM)and elevated creatine kinase.Anti MDA5 antibody is closely related to the progression and prognosis of the disease.The update of the correlation between anti MDA5 antibody and DM related clinical manifestations is reviewed in this paper.