铜催化芳烃胺化反应研究

Copper-catalyzed amination of arene

含氮芳香类化合物在天然产物、药物化学和材料科学等领域得到广泛应用,因此,通过金属催化C–N键偶联反应构建含氮芳香化合物的新方法一直是合成化学家关注的研究课题.铜作为芳烃C–N偶联胺化反应的催化剂,由于其氧化态的多样性表现出了独特的催化性能.本文综述了近年来铜催化芳香类化合物C(sp^(2))–N构建方法的研究进展,也简要描述了代表性胺类反应的反应机理.

Aromatic amines are widely used in the fields of natural products,pharmaceutical chemistry and materials science,thus the new methods of metal-catalyzed C–N bond coupling for constructing aromatic amines always have always been the focus of attention of chemists and the scientific community.Copper,as a catalyst for the amination of arenes,has attracted extensive attention due to its unique catalytic performance and variety of oxidation states.In this review,the recent progress in the construction of aromatic compounds C(sp^(2))–N catalyzed by copper is reviewed,and the reaction mechanisms of representative amination reactions are briefly described.