钯催化二烯和烯炔的不对称氢官能团化反应的研究进展

Recent progress in Pd-catalyzed asymmetric hydrofunctionalizations of dienes and enynes

不对称η^(3)-取代反应在有机合成及转化中具有重要的地位,广泛应用于天然产物及药物分子合成中.利用钯催化实现不饱和烃的不对称氢官能团化反应,因其广泛的底物普适性、高的原子经济性和立体选择性控制效果而受到诸多关注,也成为近年来该领域研究的热点.其中,相对于联烯和炔烃底物来说,钯催化的二烯和烯炔的不对称氢官能团化反应研究尚少,近年来才开始快速发展,实现了许多重要突破,并逐步发展成为一类具有高合成价值的策略.本文主要综述了自2020年以来该领域的最新研究进展,从共轭二烯、远程二烯及共轭烯炔等类型的底物出发,总结和概述了相关的研究现状、策略应用和反应机理.

Asymmetricη^(3)-substitution has played an important role in orgainc synthesis and transformation,and is widely applied to the preparations of natural products and bioactive molecules.Due to the broad substrate scope,high atom economy and concise stereocontrol ability,Pd-catalyzed asymmetric hydrofunctionalization of unsaturated hydrocarbons has emerged as a critical focus in this area.Especially,much progress has been made for the corresponding hydrofunctionalizations of dienes and enynes recently,which has gradually developed into a reliable and valuable synthetic strategy.Herein,we review the recent advance in this area since 2020.Based on the classified substrate types including conjugated dienes,skipped dienes and conjugated enynes,a comprehensive overview of the studies,strategies and mechanisms is described.