N-七氟异丙硫基邻苯二甲酰亚胺:一种广泛适应的七氟异丙硫基化试剂

N-heptafluoroisopropylthiophthalimide: a versatile heptafluoroisopropylthiolating reagent

本文报道一种稳定且广泛适应的七氟异丙硫基化试剂——N-七氟异丙硫基邻苯二甲酰亚胺(Phth-SCF(CF_(3))_(2)).该试剂通过二硫代邻苯二甲酰亚胺和七氟异丙基银的反应合成,并被应用于多种类型的七氟异丙硫基化反应,包括烷基卤代物的亲核取代反应、醇的脱氧反应、吲哚的芳香亲电取代反应、烯烃的自由基反应以及炔烃的偶联反应.

A shelf-stable and versatile heptafluoroisopropylthiolating reagent N-heptafluoroisopropylthiophthalimide (Phth-SCF(CF_(3))_(2))was developed.It is readily accessible from the reaction of di(1-phthalimidyl)disulfane with AgCF(CF_(3))_(2).The widely synthetic application of this reagent has been demonstrated by nucleophilic substitution of alkyl halides,deoxygenative heptafluoroisopropylthiolation of alcohols,electrophilic aromatic substitution of indoles,radical heptafluoroisopropylthiolation of alkenes,and cross-coupling with alkynes.