外敷透骨血竭散联合甲氨蝶呤治疗类风湿性关节炎患者的效果及RF、CRP、ESR水平变化

Efficacy of topical Touguxuejie Powder combined with methotrexate in patients with rheumatoid arthritis and changes in RF,CRP and ESR levels

目的 探究外敷透骨血竭散联合甲氨蝶呤治疗类风湿性关节炎(RA)患者的效果及类风湿因子(RF)、C反应蛋白(CRP)、红细胞沉降率(ESR)水平变化。方法 选择2019年1月到2020年12月我院收治的81例类风湿关节炎患者,按照随机数字表法分为观察组(n=41)和对照组(n=40),对照组采用甲氨蝶呤治疗,观察组在对照组基础上联合透骨血竭散外敷治疗,治疗4周后评价两组临床疗效,检测治疗前后血清RF、CRP、ESR变化,记录治疗过程中出现的不良反应,并进行对比分析。结果 治疗4周后观察组临床总有效率97.56%高于对照组82.50%(P<0.05);治疗后两组血清RF、CRP、ESR均下降,且观察组低于对照组(P<0.05);两组患者发生不良反应概率无显著差异(7.32%vs 5.00%,P>0.05)。结论 外敷透骨血竭散联合甲氨蝶呤治疗RA疗效显著,能明显改善RF、CRP、ESR相关指标水平,且不良反应少,是一种安全有效的治疗方法。

Objective To explore the efficacy of topical Touguxuejie Powder combined with methotrexate in the treatment of rheumatoid arthritis(RA)patients and the changes in rheumatoid factor(RF),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR).Methods Eighty-one patients with rheumatoid arthritis admitted to our hospital from January 2019 to December 2020 were selected and divided into observation group(n=41)and control group(n=40)according to the random number table method.The control group was treated with methotrexate, and the observation group was treated with topical Touguxuejie powder on the basis of the control group.After 4 weeks of treatment, the clinical efficacy of the two groups was evaluated.The changes of serum RF,CRP,and ESR before and after treatment were measured, and adverse reactions occurred during the treatment were recorded and submitted for comparative analysis.Results After 4 weeks of treatment, the total clinical effective rate of the observation group was higher than that of the control group(97.56% vs.82.50%,P<0.05).The serum RF,CRP,and ESR of the two groups decreased after treatment, and the observation group was lower than the control group(P<0.05).There was no significant difference in the probability of adverse reactions between the two groups(7.32% vs.5.00%,P>0.05).Conclusion Topical Touguxuejie Powder combined with methotrexate has a significant effect in the treatment of RA,which can significantly improve the levels of RF,CRP,and ESR related indicators with few adverse reactions.It is a safe and effective treatment method.