雌孕激素序贯联合坤泰胶囊治疗早发性卵巢功能不全的效果观察

Efficacy of Chinese medicine Kuntai capsule combined with sequential estrogen progesterone therapy in treatment of early-onset ovarian dysfunction

回顾性分析2018年12月至2021年12月收治的102例早发性卵巢功能不全(卵巢早衰)患者临床资料。其中对照组(51例)行雌孕激素序贯治疗,观察组(51例)行雌孕激素序贯联合坤泰胶囊治疗,均治疗3个月经周期。治疗后随访,观察组的总有效率高于对照组[94.1%(48/51)与72.6%(37/51);χ^(2)=4.07,P=0.044];对照和观察组Kupperman总分均降低[治疗前、后分别为(36.5±5.6)与(36.2±5.4)分、(18.8±2.4)与(9.2±1.2)分],评分轻度者增多(治疗前、后分别为6与5例、32与44例);血清雌二醇水平升高[治疗前、后分别为(35.9±4.4)与(82.5±6.3)pmol/L、(35.9±4.1)与(89.2±8.3)pmol/L];血清促黄体素(LH)与促卵泡激素(FSH)水平也均降低[治疗前、后对照组LH为(41.4±5.6)与(25.8±3.6)U/L、FSH为(88.6±9.3)与(34.5±4.3)U/L;观察组LH为(41.2±5.5)与(18.1±2.2)U/L、FSH为(88.6±9.2)与(25.8±3.1)U/L],治疗后观察组低于对照组。彩色超声检查子宫血流阻力指数、搏动指数均较治疗前降低,且观察组低于对照组;卵巢动脉收缩期峰值流速较治疗前增加,且观察组高于对照组。提示卵巢早衰患者应用坤泰胶囊可提高雌孕激素序贯治疗效果。

Clinical data of 102 patients with premature ovarian failure admitted to Zhang Zhongjing Hospital from December 2018 to December 2021 were retrospectively analyzed.Fifty-one patients received(control group),and another 51 patients received Chinse medicine Kuntai capsule in addition to sequential estrogen progesterone therapy(study group);both groups were treated for 3 menstrual cycles.After treatment,the total effective rate of the study group was higher than that of the control group(94.1%(48/51)vs.72.6%(37/51),χ^(2)=4.07,P=0.044).After treatment,the proportion of patients with mild Kupperman score and serum estradiol level in both groups were increased,and the proportion in study group was higher than that in the control group.The proportion of patients with moderate and severe Kupperman score and the total score decreased after treatment in both groups,and the proportion of patients with moderate Kupperman score in the study group was lower than that in the control group.Serum luteinizing hormone and folliclestimulating hormone levels were significantly decreased,and the levels in study group were lower than those in the control group.The levels of resistance index and PI were significantly decreased after treatment in both group and the study group decrease more markedly(all P<0.05).The peak systolic flow velocity level was increased after treatment in both groups and the study group increased more markedly(all P<0.05).It is suggested that the application of Chinese medicine Kuntai capsule combined with sequential estrogen progesterone therapy can effectively improve the clinical therapeutic effect,stabilize sex hormones,uterine microcirculation and effectively alleviate the condition of patients with premature ovarian failure.