表观弥散系数与胶质瘤IDH-1/1p19q基因型的相关性研究

Correlation Between Apparent Diffusion Coefficient and IDH-1/1p19q Genotype of Glioma

目的探讨ADC值与胶质瘤IDH-1/1p19q基因型间的相关性。方法回顾性分析2013年3月—2020年12月经病理证实的69例WHOⅡ/Ⅲ级神经胶质瘤患者的MRI和分子病理学检测结果,采用ROC曲线评估ADC值对胶质瘤基因型(IDH-1、1p19q)的诊断性能。结果IDH-1突变组ADC_(mean)、ADC_(min)、rADC_(mean)、rADC_(min)均分别显著高于IDH-1野生组(P<0.05、P<0.01、P<0.05、P<0.01),以rADC_(min) 0.979×10^(3) mm^(2)/s为阈值诊断IDH-1突变型与IDH-1野生型胶质瘤的效能最高(AUC=0.770),其敏感度、特异性分别为84.61%和59.09%。结论ADC可以作为无创性预测IDH-1突变型与野生型Ⅱ/Ⅲ级胶质瘤的影像学生物标志物。

Objective To investigate the correlation between ADC value and glioma IDH-1/1p19q genotype.Methods The MRI features and molecular pathological results of 69 patients with pathologically confirmed diagnosis of WHO gradeⅡ/Ⅲglioma between March 2013 and December 2020 were retrospectively analyzed.The diagnostic performance of ADC values on glioma genotypes(IDH-1,1p19q)was evaluated using the ROC curve of the subjects’working characteristics.Results The ADC_(mean),ADC_(min),rADC_(mean),and rADC_(min) in the IDH-1 mutation group were significantly higher than those in the IDH-1 wild group(P<0.05,P<0.01,P<0.05,P<0.01).The use of the rADC_(min) threshold(0.979×10^(3) mm^(2)/s)had the highest efficacy(AUC=0.770)for diagnosis of IDH-1 mutant and IDH-1 wild-type gliomas as well as sensitivity and specificity of 84.61%and 59.09%,respectively.Conclusion ADC can be used as an imaging biomarker for noninvasive prediction of IDH-1 mutant and wild-typeⅡ/Ⅲgliomas.