成纤维细胞生长因子在中枢神经系统疾病中的作用

Research progress of fibroblast growth factor in nervous system diseases

成纤维细胞生长因子(FGF)是一组家族性结构相关的蛋白多肽,与其受体构成了一个复杂的信号系统。近年来,越来越多证据表明FGF家族在中枢神经系统损伤修复中起到关键作用,主要的保护机制包括激活PI3K-Akt、过氧化物酶体增殖物激活受体(PPARγ)等信号的表达,抑制核因子-κB(NF-κB)介导的炎症反应、氧化应激、神经元的凋亡,调控神经元分化和神经元兴奋性,参与神经血管单元的保护和神经功能修复等。本文综述了FGF在脑梗死、脑出血、创伤性脑损伤、阿尔茨海默病、帕金森病、癫痫和抑郁症等中枢神经系统疾病中的最新研究进展,旨在为应用于神经系统疾病FGF药物的研发提供依据和思路。

Fibroblast growth factors(FGF)are a group of structurally related polypeptides which constitute an elaborate signaling system with their receptors.Evidence accumulated in the years suggests that the FGF family plays a key role in the repair of central nervous system injury.The main protective mechanisms include activating the expression of PI3K-Akt,peroxisome proliferator-activated receptor(PPARγ)and other signals;inhibiting NF-κB-mediated inflammatory response,oxidative stress and apoptosis;regulating neuronal differentiation and neuronal excitability as well as participating in protection of neurovascular units and nerve function repair.This paper comprehensively summarizes the latest research progress in FGF signaling related to diseases of the central nervous system such as cerebral infarction,cerebral hemorrhage,traumatic brain injury,Alzheimer’s disease,Parkinson’s disease,epilepsy and depression,aiming to provide scientific basis and reference for the development of innovative FGF drugs for the prevention and treatment of neurological diseases.