无症状糜烂性食管炎与慢性活动性胃炎相关性分析

Inverse correlation between asymptomatic erosive esophagitis and chronic active gastritis

目的:探索无症状糜烂性食管炎(asymptomatic erosive esophagitis,AEE)与慢性活动性胃炎之间的关系。方法:采用病例对照研究,选取无胃食管反流相关症状的胃镜体检人群,其中存在内镜下糜烂性食管炎的为AEE组,无内镜下糜烂性食管炎的为对照组。收集2组的人口统计学、胃镜检查结果及胃镜病理进行比较。结果:共纳入胃镜检查体检者1 818名,其中AEE组209例,对照组1 609名。多元Logistic回归分析显示,老年(P=0.008)、高体质量指数(body mass index,BMI)(P<0.001)、食管裂孔疝(P<0.001)与AEE的风险增加有关;而女性(P<0.001)、胆汁反流(P=0.007)及活动性胃炎(P=0.041)与AEE的风险降低有关。结论:慢性活动性胃炎与AEE呈负相关。

Objective To explore the correlation between asymptomatic erosive esophagitis(AEE) and chronic active gastritis. Methods In this case-control study, the individuals without gastroesophageal reflux symptoms underwent esophagogastroduodenoscopy for routine health checkup were included and divided into two groups. AEE group was consisted of subjects with erosive esophagitis but without gastroesophageal reflux symptoms. The control group was consisted of individuals with neither gastroesophageal reflux symptoms nor endoscopic erosive esophagitis. The demographics, gastroscopy and histopathologic results were collected. Results A total of 1 818 individuals were included in the study, including 209subjects in AEE group and 1 609 subjects in the control group. In multivariate Logistic regression analysis, advanced age(P=0.008), higher body mass index(P<0.001) and hiatus hernia(P<0.001) were associated with an increased risk of AEE.Female(P<0.001), bile reflux(P=0.007) and chronic active gastritis(P=0.041) were associated with a decreased risk of AEE. Conclusions Chronic active gastritis exhibited inverse relationship with AEE.