白细胞介素与脉络膜新生血管形成的关系

Interleukins and choroidal neovascularization

脉络膜新生血管形成(choroidal neovascularization,CNV)是各种脉络膜视网膜疾病常见的病理终点,是视力不可逆损害的主要病因。CNV是一个非常复杂的病理生理过程,涉及多种结构细胞、炎性细胞及炎性因子,与视网膜局部慢性炎症有关。研究表明,作为炎性细胞因子一大家族的白细胞介素类(interluelin,IL),在不同的免疫微环境中通过调节促血管生成和抗血管生成因子的表达,参与CNV的发生发展,调节IL的生成及功能可能作为潜在的治疗靶点。

Choroidal neovascularization(CNV)is a common pathological endpoint of various choroidal retinal diseases and the main cause of irreversible visual impairment in humans.The formation of CNV is a very complex pathophysiological process involving a variety of structural cells,inflammatory cells and inflammatory factors,and is related to local chronic inflammation of the retina.Studies have shown that interleukins(ILs),as a large family of inflammatory cytokines,participate in the occurrence and development of CNV by regulating the expression of pro-angiogenic and anti-angiogenic factors in different immune microenvironments,and regulating the generation and function of ILs may serve as potential therapeutic targets.