甘油三酯葡萄糖乘积指数与糖尿病血管并发症相关性的研究

Correlation between triglyceride-glucose index and diabetic vascular complications

目的探讨甘油三酯葡萄糖乘积(TyG)指数与DM血管并发症的相关性。方法选取2018年6月至2020年12月于南昌市第一医院内分泌科住院治疗的T2DM患者2790例,根据TyG水平分为Q1(6.41≤TyG<8.45,n=680)组,Q2(8.45≤TyG<8.80,n=695)组,Q3(8.80≤TyG<9.41,n=710)组及Q4(9.41≤TyG<10.43,n=705)组。结果Q1、Q2、Q3、Q4组DPN患病率、肱⁃踝脉搏波速度(baPWV)逐渐升高(P<0.05)。Pearson相关分析显示,TyG指数与DM病程、BMI、SBP、DBP、WHR、HbA1c、TC、LDL⁃C、baPWV呈正相关(P<0.05或P<0.01),与HDL⁃C呈负相关(P<0.01)。Logistic回归分析显示,TyG指数是DPN、baPWV>1800 cm/s的影响因素。结论TyG指数与T2DM患者血管并发症密切相关,可作为评估血管并发症指标。

Objective To explore the correlation between triglyceride-glucose(TyG)index and vascular complications in diabetes mellitus.Methods A total of 2790 patients with T2DM hospitalized in Endocrinology Department of Nanchang First Hospital from June 2018 to December 2020 were selected and divided into Q1(6.41≤TyG<8.45,n=680),Q2(8.45≤TyG<8.80,n=695),Q3(8.80≤TyG<9.41,n=710)and Q4(9.41≤TyG<10.43,n=705)groups.Results The prevalence of DPN and brachial-ankle pulse wave velocity(baPWV)increased gradually from Q1,Q2,Q3 to Q4 groups(P<0.05).Pearson correlation analysis showed that TyG index was positively correlated with the course of DM,BMI,SBP,DBP,WHR,HbA1c,TC,LDL-C,baPWV(P<0.05 or P<0.01),and negatively correlated with HDL-C(P<0.01).Logistic regression analysis showed that TyG index was the influencing factor of DPN and baPWV>1800 cm/s.Conclusion TyG index is closely related to the risk of vascular disease in T2DM patients,and can be used as a simple index to assess diabetic vascular complications.