摘要
Ⅰ型干扰素(INF-Ⅰ)是一类具有抗病毒和抗肿瘤活性的细胞因子,近年来其在自身炎症和自身免疫性疾病发病中的作用日益受到重视。病毒感染、自身免疫性疾病、干扰素治疗等多种因素均可引起INF-Ⅰ水平升高,并通过直接和间接途径造成肾脏损伤。也有相当一部分患者因调节干扰素信号通路的基因功能异常导致INF-Ⅰ水平升高,又称Ⅰ型干扰素病。研究表明原发性和继发性INF-Ⅰ升高导致肾脏损伤的患者在肾组织病理上存在共同之处,可表现为塌陷型肾小球病、炎症性增殖、血管病变或管网状包涵体等。基因组医学的发展为深入了解和精准诊治这类疾病提供了新的思路和方向。
Type Ⅰ interferon( INF-Ⅰ) is a group of cytokines that mediate anti-viral and anti-neoplastic immunity,and its role in the pathogenesis of autoinflammation and autoimmune diseases has attracted more and more attention in recent years. Increased INF-Ⅰ is observed in the context of viral infections,autoimmunity,and interferon therapy,resulting in renal injury through direct and indirect pathways. Among them,there are also a considerable number of patients,in which the elevated levels of INF-Ⅰ are associated with abnormal function of genes regulating INF-Ⅰsignaling pathway,also known as type Ⅰ interferonopathies. Studies have shown that these renal-involved patients share distinct histopathological features,such as collapsing glomerulopathy,inflammatory-proliferative pattern,vascular lesions or tubulo-reticular inclusions. The development of genomic medicine has provided us with new insight into precise diagnosis and treatment for these patients.
作者
安玉
梁丹丹(综述)
刘志红(审校)
AN Yu;LIANG Dandan;LIU Zhihong(National Clinical Research Center of Kidney Diseases,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210016,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2023年第1期53-59,共7页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
国家自然科学基金专项项目(32141004)。
