急性肾损伤进展为慢性肾脏病的机制

Mechanisms of progression from acute kidney injury to chronic kidney disease

急性肾损伤(AKI)是慢性肾脏病(CKD)发生和发展的重要危险因素。即使是轻微的AKI也可能产生不良后果,并可能发展为肾脏纤维化,这是所有终末期肾病的最终结果。因此,深入了解这种转变机制以阻止AKI向CKD进展至关重要。本文就AKI向CKD进展的细胞和分子机制及潜在治疗靶点的研究作一综述。

Acute kidney injury(AKI)is an important risk factor for the occurrence and development of chronic kidney disease(CKD).Even milder AKI could have adverse consequences and could progress to renal fibrosis,which is the ultimate common pathway for terminal kidney diseases.Therefore,it is crucial to gain an in-depth understanding of the mechanism to block the transition from AKI to CKD.This article reviews the cellular and molecular mechanisms of the transition from AKI to CKD and the research progress of potential therapeutic targets.