恩格列净制备过程中一种手性脱碘杂质的合成与表征

Synthesis and Characterization of a Chiral Deiodinated Impurity Derived from the Preparation of Empagliflozin

报道了恩格列净制备过程中一种手性脱碘杂质的合成方法,并对其进行了表征。为控制恩格列净的产品质量,本研究基于其生产工艺,分离提纯了一种手性脱碘杂质,通过^(1)H-NMR、^(13)C-NMR等表征确定了结构。同时,设计了一条新路线高效合成了该杂质,以期为恩格列净原料药的质量和安全性研究提供技术支持。

A chiral deiodinated impurity of an intermediate of empagliflozin was synthesized and characterized in this study. Firstly, the deiodinated impurities of the intermediate was separated and characterized by ^(1)H-NMR,^(13)C-NMR, et al. Then, an efficient route to access the impurity was developed, which provides a technical support for the quality and safety study of empaliflozin.