血液中中性粒细胞/淋巴细胞比值(NLR)与绝经后女性CAD关系的研究

Analysis of the Relationship between Neutrophil/Lymphocyte Ratio and CAD in Postmenopausal Women

目的::探讨研究血液中中性粒细胞/淋巴细胞比值(NLR)与绝经后女性CAD关系,为临床治疗绝经期女性CAD患者冠状动脉病变程度提供有力依据。方法:选取本院2020年6月至2021年6月经冠状动脉造影术(CAG)确诊的260例绝经后女性CAD患者作为病例组,同时选取同时期260例疑诊为CAD,但经临床医师和辅助检测排除CAD的女性绝经期者作为对照组,进行回顾性分析。结果:两组患者临床资料对比,BMI、绝经年龄、CAD家族史均无统计学意义(P>0.05);研究组患者年龄大、绝经时间长,以及合并有高血压、糖尿病的患者经统计学分析,均有统计学意义(P<0.05)。实验室指标中可见,病例组白细胞、NLR、TG、天冬转氨酶相比明显高于对照组,有统计学差异(P<0.05);PCT、HDL、纤维蛋白、ApoA相比明显低于对照组,有统计学差异(P<0.05)。CAD患者重度组119例、中度组72例、轻度组69例。统计学多组间比较采用方差分析,F=3.538,P<0.05,差异有统计学意义。组间两两比较用LSD法,轻度组与中度组比较,差异无统计学意义(P>0.05);轻度组与重度组比较,中度组与重度组比较,差异均有统计学意义(P<0.05)。Logistic回归方程中得出,年龄、高血压、NLR、TG、纤维蛋白均为绝经后女性冠心病(CAD)的独立危险因素。结论:规检测血常规,NLR的检测方便,其价格低廉,能让临床医师早期发现高危患者,能有效评估和预测绝经后女性CAD冠状动脉的严重程度。

Objective:To investigate the relationship between neutrophil/lymphocyte ratio(NLR)in blood and CAD in postmenopausal women,and to provide a strong basis for clinical treatment of coronary artery lesions in postmenopausal women with CAD.Methods:A total of 260 postmenopausal female CAD patients diagnosed by coronary angiography(CAG)in our hospital from June 2020 to June 2021 were selected as the case group.At the same time,260 women with suspected CAD during the same period,but whose CAD was ruled out by clinicians and ancillary tests,were selected as a control group.A retrospective analysis was conducted.Results:There was no significant difference in BMI,age at menopause and family history of CAD between the two groups of patients(P>0.05).Patients in the study group with older age,longer menopause,and combined hypertension and diabetes mellitus were statistically analyzed(P<0.05).It can be seen from the laboratory indicators that the white blood cells,NLR,TG and aspartate aminotransferase of the case group were significantly higher than those of the control group,with statistical differences(P<0.05);PCT,HDL,fibrin,and ApoA were significantly lower than those of the control group,there was a statistical difference(P<0.05).There were 119 cases in the severe group,72 cases in the moderate group,and 69 cases in the mild group of CAD patients.Statistical multi-group comparison was performed by ANOVA,F=3.538,P<0.05,the difference was statistically significant.The difference was not statistically significant(P>0.05)when comparing the mild group with the moderate group by the LSD method between two groups,and the difference was statistically significant(P<0.05)when comparing the mild group with the severe group and the moderate group with the severe group.Logistic regression equation showed that age,hypertension,NLR,TG and fibrin were independent risk factors for coronary heart disease(CAD)in postmenopausal women.Conclusion:The NLR is a convenient and inexpensive blood test that allows clinicians to identify high-risk patients early and can effectively assess and predict the severity of CAD coronary arteries in postmenopausal women.