甲巯咪唑软膏治疗甲亢口服药不耐受患者的临床观察

Clinical Observation of Methimazole Ointment in the Treatment of Oral Drug Intolerance in Patients with Hyperthyroidism

目的评价对甲巯咪唑口服不耐受甲状腺功能亢进症(甲亢)患者予以甲巯咪唑软膏外用治疗的预后效果,为甲亢疾病临床治疗提供参考。方法选择我院2018年6月至2019年6月收治的甲巯咪唑口服不耐受的甲亢疾病患者(n=80),根据用药方案进行分组治疗,采取1∶1比例法,对照组与观察组例数相同,本研究获得伦理委员会批准。对照组40例甲亢患者采取丙硫氧嘧啶治疗,观察组40例甲亢患者采取甲巯咪唑软膏外用治疗。比较对照组与观察组甲亢疾病患者的治疗情况,包括治疗效果以及促甲状腺激素(TSH)、游离甲状腺素(FT_(4))、游离三碘甲状腺原氨酸(FT_(3))甲状腺功能水平指标改善情况。结果治疗前,两组甲亢患者的TSH、FT_(4)、FT_(3)甲状腺功能水平差异无显著性,P>0.05;治疗后,两组甲亢患者的甲状腺功能水平改善,观察组TSH(2.33±0.35)mol/L、FT_(4)(21.08±2.50)pg/mL、FT_(3)(6.12±0.78)pg/mL水平均低于对照组,P<0.05。组间治疗效果比较,观察组甲亢患者治疗总有效率(95.00%)明显高于对照组(70.00%),P<0.05。结论针对甲巯咪唑口服不耐受的甲亢疾病患者行甲巯咪唑软膏外用治疗是可行的,可明显改善患者的甲状腺功能,促进患者预后。

Objective To evaluate the prognostic effect of topical treatment of methimazole ointment in patients with hyperthyroidism(hyperthyroidism)who are intolerant to the oral drug methimazole tablets,and to provide a reference for the clinical treatment of hyperthyroidism.Method Select patients with hyperthyroidism intolerant to oral medications(n=80)who were admitted to our hospital from June 2018 to June 2019,and treat them in groups according to the medication regimen,adopting the 1∶1 ratio method,control The number of cases in the observation group was the same as that in the observation group,which was approved by the ethics committee.40 patients with hyperthyroidism in the control group were treated with propylthiouracil,and 40 patients in the observation group with hyperthyroidism were treated with methimazole ointment.Compare the treatment of patients with hyperthyroidism in the control group and the observation group,including the therapeutic effect,thyroid stimulating hormone(TSH),free thyroxine(FT_(4)),and free triiodothyronine(FT_(3)).Improvement of thyroid function level indicators.Results Before treatment,there was no significant difference in TSH,FT_(4),FT_(3) thyroid function levels between the two groups of hyperthyroidism patients,P>0.05;after treatment,the thyroid function level of the two groups of hyperthyroidism patients improved,and the average TSH(2.33±0.35)mol/L,FT_(4)(21.08±2.50)pg/mL and FT_(3)(6.12±0.78)pg/mL levels of the observation group were lower than the control group,P<0.05.Comparing the treatment effects between the groups,the total effective rate of 95.00%for patients with hyperthyroidism in the observation group was significantly higher than that of the control group 70.00%,P<0.05.Conclusion It is still feasible to treat patients with hyperthyroidism who are intolerant of oral medications with methimazole ointment,and the thyroid function index level of the patients has improved significantly,which promotes the prognosis of the patients.