重复经颅磁刺激联合语言训练对孤独症患儿语言康复的影响

Effect of repetitive transcranial magnetic stimulation combined with language training on language rehabilitation in children with autism

目的探讨重复经颅磁刺激联合语言训练对孤独症患儿语言康复的影响。方法将本院收治的102例孤独症患儿以随机抽签法分为对照组、观察组,各51例。对照组给予语言训练治疗,观察组给予重复经颅磁刺激联合语言训练治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的儿童孤独症评定量表(CARS)、孤独症行为评定量表(ABC)评分均低于对照组,语言行为评估量表评分高于对照组(P<0.05)。治疗后,观察组的脑源性神经营养因子(BDNF)、Bcl-2蛋白表达水平均高于对照组(P<0.05)。结论重复经颅磁刺激联合语言训练治疗孤独症患儿的效果显著,能够改善患儿的孤独症状和语言功能,上调BDNF、Bcl-2蛋白表达水平,值得临床推广。

Objective To explore the effect of repetitive transcranial magnetic stimulation combined with language training on language rehabilitation in children with autism.Methods A total of 102 children with autism admitted in our hospital were randomly divided into control group and observation group,with 51 cases in each group.The control group was treated with language training,and the observation group was treated with repetitive transcranial magnetic stimulation combined with language training.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the scores of Child Autism Rating Scale(CARS)and Autism Behavior Checklist(ABC)in the observation group were lower than those in the control group,while the score of language behavior assessment scale was higher than that in the control group(P<0.05).After treatment,the expression levels of brain-derived neurotrophic factor(BDNF)and Bcl-2 protein in the observation group were higher than those in the control group(P<0.05).Conclusion Repetitive transcranial magnetic stimulation combined with language training in the treatment of children with autism has a significant effect.It can improve the autistic symptoms and language function of children,and up-regulate the expression levels of BDNF and Bcl-2 protein,which is worthy of clinical promotion.