葛花解酲汤灌肠治疗重症急性酒精中毒临床观察

Clinical Observation on Gehua Jiexing Decoction Enema in the Treatment of Severe Acute Alcoholism

目的研究重症急性酒精中毒应用加味葛花解酲汤治疗的效果。方法选取2018年8月—2020年7月广水市第二人民医院收治的68例重症急性酒精中毒患者为研究对象,按随机数字表法分组,各34例。所有患者均于入院后行插管洗胃、吸氧、催吐及补给维生素C等治疗,在此基础上,对照组行盐酸纳洛酮注射液治疗,观察组在对照组基础上加用加味葛花解酲汤治疗,对比2组恢复时间、并发症发生率及治疗前后炎性因子水平。结果与对照组比较,观察组血压、呼吸、体温恢复时间及清醒时间均更短(P<0.05);与对照组比较,观察组治疗后白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均更低(P<0.05);并发症发生率比较,观察组为2.94%(1/34),低于对照组的26.47%(9/34),差异有统计学意义(P<0.05)。结论重症急性酒精中毒应用加味葛花解酲汤治疗的效果显著,可有效缩短患者清醒时间,减少并发症的发生,且可减轻机体炎症反应。

Objective To study the effect of Gehua Jiexing decoction enema in the treatment of severe acute alcoholism.Methods A total of 68 patients with severe acute alcoholism in Guangshui Second People’s Hospital from August 2018 to July 2020 were selected as the study subjects.After admission,all patients were treated with intubation for gastric lavage,oxygen inhalation,vomiting and vitamin C supplementation.On this basis,the control group was treated with Naloxone,and the observation group was treated with Gehua Jiexing decoction enema.The recovery time,complication rate and the level of inflammatory factors before and after treatment were compared between the two groups.Results Compared with the control group,the recovery time of blood pressure,respiration,body temperature and wakefulness time in the observation group were shorter(P<0.05).Compared with control group,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in observation group were lower after treatment(P<0.05).The incidence of complications in the observation group was 2.94%(1/34),lower than that in the control group 26.47%(9/34),and the difference was statistically significant(P<0.05).Conclusion Gehua Jiexing decoction enema in the treatment of severe acute alcoholism is effective,can effectively shorten the time of wakefulness,and reduce complications and the body inflammatory reaction.