奥硝唑注射液和头孢唑肟钠联合治疗慢性阑尾炎的效果分析

Effect Analysis of Ornidazole Injection and Cefazoxime Sodium in the Treatment of Chronic Appendicitis

目的分析奥硝唑注射液与头孢唑肟钠联合方案用于对慢性阑尾炎的治疗效果。方法选取2021年10月至2022年10期间院内收治的慢性阑尾炎患者80例,通过随机原则分成对照组及观察组,各40例,分别采用头孢唑肟钠、头孢唑肟钠联合奥硝唑方案进行治疗,比较两组治疗效果差异。结果观察组治疗总有效率92.50%高于对照组75.00%(P<0.05);观察组临床表现消失时间均缩短于对照组(P<0.05);两组治疗前炎性因子指标差异均无统计学意义(P>0.05);两组治疗后炎性因子指标水平均低于治疗前(P<0.05);观察组治疗后炎性因子指标水平均低于对照组(P<0.05);两组治疗前生活质量评分差异无统计学意义(P>0.05);两组治疗后生活质量评分高于干预前(P<0.05);观察组治疗后生活质量评分高于对照组(P<0.05);观察组不良反应总发生率7.50%低于对照组的27.50%(P<0.05);两组不良反应均比较轻微,经对症治疗后,明显好转,且并未发生严重不良反应。结论采取奥硝唑注射液和头孢唑肟钠联合方案治疗慢性阑尾炎能够获得良好的临床效果,且在尽快缓解临床表现、减轻炎性因子水平、改善生活质量及降低不良反应发生风险方面获得比较理想的临床价值。

Objective To analyze the therapeutic effect of ornidazole injection combined with cefazoxime sodium on chronic appendicitis.Methods Eighty patients with chronic appendicitis admitted to the hospital from October 2021 to October 2022 were randomly divided into the control group and the observation group,with 40 patients in each group,and treated with cefazoxime sodium,cefazoxime sodium combined with ornidazole,respectively.The difference between the two groups was compared.Results The total effective rate in the observation group was 92.50%higher than that in the control group(75.00%,P<0.05).The disappearance time of clinical manifestations in the observation group was shorter than that in the control group(P<0.05).There was no statistically significant difference in inflammatory factor indexes between the two groups before treatment(P>0.05).The levels of inflammatory factors in both groups after treatment were lower than those before treatment(P<0.05).The levels of inflammatory factors in the observation group after treatment were lower than those in the control group and before treatment(P<0.05).There was no significant difference in quality of life scores between the two groups before treatment(P>0.05).The score of quality of life in the two groups after treatment was higher than that before intervention(P>0.05).The score of quality of life in the observation group after treatment was higher than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group was 7.50%lower than that in the control group(27.50%,P<0.05).The adverse reactions in both groups were mild,and after symptomatic treatment,they were significantly improved,and no serious adverse reactions occurred.Conclusion The combination of ornidazole injection and cefazoxime sodium in the treatment of chronic appendicitis can achieve good clinical results,and obtain ideal clinical value in alleviating clinical symptoms as soon as possible,reducing the level of inflammatory factors,improving the quality of life and reducing the risk of adverse reactions.