碳酸锂对癫痫性精神病患者攻击性的疗效研究

Efficacy of Lithium Carbonate on Aggression in Patients with Epileptic Psychosis

目的:探讨碳酸锂对癫痫性精神病患者攻击性的疗效。方法:选择2021年3月至2022年2月赣州市第三人民医院收治的癫痫性精神病患者100例,根据患者入院单号将其分为对照组和研究组,各50例。两组均进行健康宣教、心理疏导,在此基础上,对照组采用常规治疗,研究组在对照组基础上加用碳酸锂治疗,两组均治疗4周。比较两组治疗4周后临床疗效[临床疗效总印象量表(CGI)],入院时、第2周、第4周攻击行为[修订版外显攻击行为量表(MOAS)],治疗前、治疗4周后血生化指标[脑源性神经营养因子(BDNF)、神经生长因子(NGF)],及治疗2周、4周不良反应[药物不良反应量表(TESS)]。结果:研究组疗效指数评分高于对照组,病情严重程度、疗效总评分低于对照组,差异有统计学意义(P<0.05);两组治疗2周、4周MOAS评分低于入院时,治疗4周MOAS评分低于治疗2周,且研究组MOAS低于对照组,差异有统计学意义(P<0.05);两组治疗4周BDNF、NGF水平高于治疗前,且研究组高于治疗组,差异有统计学意义(P<0.05);两组治疗2周、治疗4周TESS评分对比,差异无统计学意义(P>0.05)。结论:碳酸锂治疗癫痫性精神病患者疗效显著,可减少患者攻击性行为,促进患者神经元修复,且安全性较好。

Objective:To investigate the effect of lithium carbonate on aggression in patients with epileptic psychosis.Methods:A total of 100 patients with epileptic psychosis admitted to The Third People's Hospital of Ganzhou from March 2021 to February 2022 were selected,divided into control group and study group according to their admission numbers,with 50 cases in each group.Both groups were given health education and psychological counseling.On this basis,the control group was given conventional treatment,and the study group was given lithium carbonate treatment on the basis of the control group.Both groups were treated for 4 weeks.Compared with the clinical efficacy of the two groups after 4 weeks of treatment[Clinical Response Total Impression Scale(CGI)],aggressive behavior[Modified Explicit Aggressive Behavior Scale(MOAS)]at admission,the second week,and the fourth week,before treatment,blood biochemical indicators[brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)]after 4 weeks of treatment,and adverse reactions[adverse drug reaction scale(TESS)]after 2 weeks and 4 weeks of treatment.Results:The curative effect index score of the study group was higher than that of the control group,and the severity of the disease and the overall curative effect score were lower than those of the control group,and the difference was statistically significant(P<0.05).The MOAS score in the 4th week was lower than that in the 2nd week of treatment,and the MOAS in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in TESS scores between the two groups after 2 weeks of treatment and 4 weeks after treatment(P>0.05).Conclusion:Lithium carbonate has a significant effect in the treatment of epileptic psychotic patients,can reduce the aggressive behavior of patients,and promote neuron repair in patients with good safety.