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阿瑞匹坦在肺癌含铂化疗方案所致化疗相关性恶心呕吐中的预防效果

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摘要 目的:探讨阿瑞匹坦在肺癌含铂化疗方案所致化疗相关性恶心呕吐中的预防效果。方法:选取2020年2月至2022年2月本院收治的106例肺癌含铂化疗方案所致恶心呕吐患者为研究对象,将受试者根据随机数字表法进行分组,各53例,所有患者均给予地塞米松,对照组与研究组患者在此基础上分别给予托烷司琼与阿瑞匹坦,对比两组的治疗效果、恶心呕吐持续时间、不良反应发生率、癌因性疲乏及生活质量评分变化。结果:与对照组患者治疗总有效率(79.25%)相比,研究组患者(94.34%)更高,两组比较差异明显(P<0.05);研究组患者恶心、呕吐持续时间较对照组更短,两组比较差异明显(P<0.05);与对照组患者不良反应发生率(18.87%)相比,研究组患者(5.66%)更低,两组比较差异明显(P<0.05);治疗后两组PFS各维度及总分较治疗前均明显降低,且研究组较对照组更低,两组之间相比差异明显(P<0.05);治疗后两组FLIE各维度评分较治疗前均明显提高,且研究组显著高于对照组(P<0.05)。结论:阿瑞匹坦可有效缓解恶心呕吐症状,缩短持续时间,降低不良反应发生率,并使患者的生活质量和癌因性疲乏得到改善,在肺癌含铂化疗方案所致化疗相关性恶心呕吐治疗中较托烷司琼更具优势。
作者 刘颖颖 张亚
机构地区 聊城市肿瘤医院
出处 《中外女性健康研究》 2023年第3期120-122,共3页 Women's Health Research
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