摘要
In mammals,both male and female gonads are derived from the bipotential gonadal primordium,i.e.,the genital ridge.Primordial germ cells(PGCs)are the germ cell progenitors that arise from the extraembryonic ectoderm,migrate through the hindgut endoderm,and reach the genital ridge before sex determination[1].Both Sertoli cells and granulosa cells are derived from somatic cells in undifferentiated genital ridges.The differentiation of germ cells and gonadal somatic cells during gonad development is regulated by various factors,including transcription factors,epigenetic regulators,and environmental factors.The interactions between germ cells and somatic cells also play critical roles in gonad development and PGC differentiation.
基金
supported by the National Key R&D Program of China(Grant No.2018YFA0107700)
the National Natural Science Foundation of China(Grant Nos.32170855 and 31970785).
