甲硝唑栓联合雌激素软膏治疗老年阴道炎患者的疗效及血清FSH、E2水平影响评价

Efficacy of Metronidazole Suppository Combined with Estrogen Ointment in the Treatment of Senile Patients with Vaginitis and the Influence of Se⁃rum FSH and E2 Levels

目的 探讨老年罹患阴道炎的患者在甲硝唑给药基础上,联合雌激素软膏的治疗效果及对血清FSH、E2水平的影响。方法 随机选取2019年1月—2021年1月莱西市人民医院妇科收治的老年罹患阴道炎患者100例,按照随机法分为两组,对照组50例患者应用甲硝唑栓给药方案治疗,观察组50例在此基础上加用雌激素软膏,对比两组总有效率、阴道内环境评分、血清促卵泡生成素(FSH)及雌二醇(E2)水平、主要症状占比、阴道脱落细胞成熟指数、生活质量评分及复发率。结果 观察组总有效率为98.00%,优于对照组80.00%,差异有统计学意义(χ^(2)=8.274,P<0.05)。治疗前,两组阴道炎症症状、健康状况评分对比,差异无统计学意义(P>0.05);治疗后,两组阴道炎症症状评分均降低,阴道健康状况评分均升高,且观察组改善更为显著,差异有统计学意义(P<0.05)。治疗前,两组FSH、E2指标对比,差异无统计学意义(P>0.05);治疗后,两组FSH均有上升,E2均有降低,观察组改善更为显著,差异有统计学意义(P<0.05)。治疗后,观察组阴道壁红肿、阴道灼热、阴道分泌物增多、阴道疼痛占比均低于对照组,差异有统计学意义(P<0.05)。治疗前,阴道脱落细胞成熟指数、SF-36量表评分对比,差异无统计学意义(P>0.05);治疗后,两组各项分值均有上升,且观察组改善更为显著,差异有统计学意义(P<0.05)。6个月后,观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论 针对临床收治的老年阴道炎患者,在应用甲硝唑栓的基础上加用雌激素胶囊,可提高临床总有效率,改善阴道内环境及激素水平,促进症状消除,并可提高阴道脱落细胞成熟指数及生活质量,降低复发率,应用价值显著。

Objective To explore the treatment effect of estrogen ointment combined with metronidazole on serum FSH and E2 levels in elderly patients with vaginitis.Methods A total of 100 elderly patients with vaginitis admitted to the department of gynecology of Laixi People´s Hospital from January 2019 to January 2021 were randomly selected and divided into two groups according the random methhod.50 patients in the control group were treated with metronida⁃zole,and 50 patients in the observation group were treated with estrogen ointment on the basis of the control group.The total effective rate,vaginal environment score,serum follicle stimulating hormone(FSH)index and estradiol(E2)index,the proportion of main symptoms,vaginal shedding cell maturity index,quality of life score and recurrence rate were compared between the two groups.Results The total effective rate of the observation group was 98.00%better than that of the control group 80.00%,and the difference was statistically significant(χ^(2)=8.274,P<0.05).Before treat⁃ment,in terms of symptoms and health status of vaginitis between the two groups were compared,the difference was not statistically significant(P>0.05);after treatment,the scores of evaluation of symptoms of vaginal inflammation were decreased,and the scores of vaginal health status were increased in two groups,and the improvement in the observa⁃tion group was more significant,the difference was statistically significant(P<0.05).Before treatment,there was no sta⁃tistically significant difference in FSH and E2 indexes between the two groups(P>0.05);after treatment,FSH was in⁃creased and E2 was decreased in groups groups,and the improvement in the observation group was more significant,the difference was statistically significant(P<0.05).After treatment,redness and swelling of vaginal wall,vaginal burn⁃ing,increased vaginal secretions and vaginal pain of the observation group,were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant differ⁃ence in the maturity index of vaginal exfoliated cells and the score of SF-36 scale between the two groups(P>0.05);af⁃ter treatment,all evaluation scores increased in two groups,and the improvement in the observation group was more significant,the difference was statistically significant(P<0.05).After 6 months,and the recurrence rate in the observa⁃tion group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion For elderly patients with vaginitis in clinical treatment,on the basis of the application of metronidazole suppository,taking estrogen capsules can improve the clinical total effective rate,improve the vaginal environment and hormone levels,promote the elimination of symptoms,improve the maturity index of vaginal shedding cells and quality of life,reduce the recurrence rate,and significant application value.