奥美拉唑与雷尼替丁治疗十二指肠溃疡的疗效对比分析

Comparative Analysis of the Efficacy of Omeprazole and Ranitidine in the Treatment of Duodenal Ulcer

目的 研究奥美拉唑与雷尼替丁治疗十二指肠溃疡疗效对比分析。方法 随机选择2021年3—11月吉林省某三甲医院消化内科治疗的100例十二指肠溃疡患者为研究对象,根据随机平均分配的原则将其分为对照组和观察组,各50例,对照组应用雷尼替丁,观察组应用奥美拉唑,对比分析治疗十二指肠溃疡的治疗总有效率、复发情况和幽门螺杆菌根除率。结果 观察组治疗总有效率(96.00%)高于对照组(82.00%),差异有统计学意义(χ^(2)=5.005,P<0.05);观察组复发率为2.00%(1/50),低于对照组的24.00%(12/50),差异有统计学意义(χ^(2)=10.698,P<0.05)。观察组Hp根除率为94.00%(47/50),高于对照组的72.00%(36/50),差异有统计学意义(χ^(2)=8.575,P<0.05);观察组不良反应发生率为6.00%(3/50),低于对照组的24.00%(12/50),差异有统计学意义(χ^(2)=6.353,P<0.05)。结论 与雷尼替丁相比较,奥美拉唑治疗十二指肠溃疡可以有效提升治疗总有效率,降低炎症反应水平,减少复发,并且能提高幽门螺杆菌根除情况,效果显著。

Objective To study the comparative analysis of the efficacy of omeprazole and ranitidine in the treatment of duodenal ulcer.Methods 100 patients with duodenal ulcer treated in the Department of Gastroenterology of a ter⁃tiary hospital in Jilin Province from March to November 2021 were randomly selected as the study subjects,and they were divided into a control group and an observation group of 50 cases each according to the principle of randomized equal allocation,with the control group applying ranitidine and the observation group applying omeprazole.The total therapeutic efficiency,recurrence and Hp eradication rate of the treatment of duodenal ulcer were observed and com⁃paratively analyzed.Results The total response rate(96.00%)in the observation group was higher than 82.00%in the control group,the difference was statistically significant(χ^(2)=5.005,P<0.05);the recurrence rate in the observation group was 2.00%(1/50),which was lower than 24.00%(12/50)in the control group,the difference was statistically sig⁃nificant(χ^(2)=10.698,P<0.05).The Hp eradication rate in the observation group was 94.00%(47/50),which was higher than 72.00%(36/50)in the control group,and the difference was statistically significant(χ^(2)=8.575,P<0.05);the inci⁃dence of adverse reactions in the observation group was 6.00%(3/50),which was lower than 24.00%(12/50)in the control group,the difference was statistically significant(χ^(2)=6.353,P<0.05).Conclusion Compared with ranitidine,omeprazole treatment for duodenal ulcer can effectively improve the overall efficiency of treatment,reduce the level of inflammatory response,reduce recurrence,and improve the eradication of H.pylori,with significant effect.