小儿咳喘宁口服液联合特布他林治疗儿童急性支气管炎的临床研究

Clinical study on Xiaoer Kechuanning Oral Liquid combined with terbutaline in treatment of acute bronchitis in children

目的探讨小儿咳喘宁口服液联合硫酸特布他林雾化吸入用溶液治疗儿童急性支气管炎的临床疗效。方法选取2020年2月—2022年5月在漯河市中心医院就诊的84例急性支气管炎患儿,根据随机数字表法分为对照组和治疗组,每组各42例。对照组患儿雾化吸入硫酸特布他林雾化吸入用溶液,体质量≤20 kg,2.5 mg加入1 mL生理盐水雾化吸入,体质量>20 kg,5 mg加入2 mL生理盐水雾化吸入,2次/d。治疗组在对照组治疗的基础上口服小儿咳喘宁口服液,3~4岁剂量5 mL/次,5岁及以上剂量10 mL/次,3次/d。两组患儿连续治疗7 d。观察两组的临床疗效,比较两组患儿症状改善时间、血气指标、血清炎症因子。结果治疗后,治疗组的总有效率为95.24%,明显高于对照组的总有效率80.95%,组间比较差异有统计学意义(P<0.05)。治疗后,治疗组的体温复常时间、止咳时间、肺啰音消失时间、咯痰消失时间均明显短于对照组,差异有统计学意义(P<0.05)。治疗后,两组的血氧分压、氧合指数高于治疗前,二氧化碳总量低于治疗前(P<0.05);治疗组的血氧分压、氧合指数高于对照组,二氧化碳总量低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的血清白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)水平低于治疗前(P<0.05),且治疗组的血清IL-2、TNF-α、IL-8水平低于对照组(P<0.05)。结论小儿咳喘宁口服液联合硫酸特布他林雾化吸入用溶液治疗儿童急性支气管炎具有较好的临床疗效,能减轻临床症状,改善血气指标,降低炎症反应,并且安全性良好。

Objective To investigate the clinical effect of Xiaoer Kechuanning Oral Liquid combined with Terbutaline Sulfate Nebuliser Solution in treatment of acute bronchitis in children.Methods Children(84 cases)with acute bronchitis in Luohe Central Hospital from February 2020 to May 2022 were divided into control and treatment groups according to the random number table method,and each group had 42 cases.Children in the control group were given aerosol inhalation of Terbutaline Sulfate Nebuliser Solution,the body mass≤20 kg with 2.5 mg added into 1 mL normal saline,and the body mass above 20 kg with 5 mg added into 2 mL normal saline,twice daily.Children in the treatment group were po administered with Xiaoer Kechuanning Oral Liquid on the basis of the control group,with the dose 5 mL/time of 3—4 years old,and the dose 10 mL/time of above 5 years old,three times daily.Children in two groups were treated for 7 d.After treatment,the clinical efficacies were evaluated,and the symptom improvement time,the blood gas index,and the serum inflammatory factor levels in two groups were compared.Results After treatment,the total effective rate of the treatment group was 95.24%,significantly higher than that of the control group of 80.95%,and the difference was statistically significant(P<0.05).After treatment,the temperature normalization time,cough relief time,rale disappearance time,and sputum disappearance time in the treatment group were significantly shorter than those in the control group(P<0.05).After treatment the partial pressure of blood oxygen and oxygenation index in two groups were higher than those before treatment,but the total amount of carbon dioxide in two groups was lower than that before treatment(P<0.05).The partial pressure of blood oxygen and oxygenation index in the treatment group were higher than those in the control group,but the total amount of carbon dioxide in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the serum levels of IL-2,TNF-α,and IL-8 in the two groups were lower than those before treatment(P<0.05),and the serum levels of IL-2,TNF-α,and IL-8 in the treatment group were lower than those in the control group(P<0.05).Conclusion Xiaoer Kechuanning Oral Liquid combined with Terbutaline Sulfate Nebuliser Solution has clinical curative effect in treatment of acute bronchitis in children,can alleviate clinical symptoms,improve blood gas indicators,reduce inflammatory reaction,with good safety.