姜黄素调控非编码RNA抗肿瘤的研究进展

Advances on curcumin regulating non-coding RNA against tumor

姜黄素是姜黄中一种小分子多酚化合物,是姜黄发挥生物活性的最主要成分,具有抗炎、抗氧化、抗病毒、抗肿瘤等广泛的药理作用。近年来,非编码RNA(ncRNA)作为姜黄素潜在的治疗靶点被广泛研究。姜黄素可通过ncRNA影响调控肿瘤细胞增殖、凋亡和迁移的关键信号通路或直接作用于相关蛋白进而发挥抗肿瘤作用。综述了姜黄素参与调控微小RNA(miRNA)、长链非编码RNA(LncRNA)和环状RNA(circRNA)发挥抗肿瘤作用的情况,希望对姜黄素的抗肿瘤研究提供参考依据。

Curcumin is a kind of small molecular polyphenol compound in Curcumae Longae Rhizoma,which is the most important component in Curcumae Longae Rhizoma to exert biological activity,and has a wide range of pharmacological effects,such as antiinflammatory,antioxidant,antiviral,and anti-tumor,etc.In recent years,non-coding RNA(ncRNA)has been widely studied as a potential therapeutic target of curcumin.Curcumin can play an anti-tumor role by influencing the key signal pathway regulating the proliferation,apoptosis,and migration of tumor cells through ncRNA or directly acting on related proteins.This paper reviews antitumor activity of curcumin in regulating microRNA(miRNA),long-chain non-coding RNA(LncRNA)and circular RNA(circRNA),hoping to provide reference for the anti-tumor research of curcumin.