作用于5-羟色胺受体的抗偏头痛药物的研究进展

Research progress on anti-migraine drugs acting on 5-hydroxytryptamine receptor

偏头痛是世界范围内致残的主要原因。5-羟色胺(5-HT)受体在偏头痛中发挥不可替代的作用,其中5-HT1、5-HT2、5-HT3和5-HT7受体是在偏头痛、神经性疼痛中研究最多的受体。偏头痛的早期治疗药物包括特异性药物,如曲坦类药物和麦角类生物碱。拉米地坦作为一种5-HT1F受体激动剂在不同人群中具有较好优势。总结了5-HT受体参与偏头痛的发病机制和药物作用机制,归纳了作用于5-HT受体的抗偏头痛药物曲坦类药物、麦角类生物碱和拉米地坦,以期为偏头痛治疗提供新的思路。

Migraine is the main cause of disability worldwide.5-Hydroxytryptamine(5-HT)receptors play an irreplaceable role in migraine,and 5-HT1,5-HT2,5-HT3,and 5-HT7 receptors are the most studied receptors in migraine and neuropathic pain.Early treatment drugs for migraine include specific drugs,such as triptans and ergot alkaloids.As a 5-HT1F receptor agonist,lamiditan has better advantages in different populations.In this paper,we summarized the pathogenesis and drug action mechanism of 5-HT receptor in migraine,and summarized the anti-migraine drugs,such as triptans,ergot alkaloids and lamiditan,which act on 5-HT receptor,in order to provide new ideas for the treatment of migraine.