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通淋汤联合坦索罗辛对高龄晚期前列腺癌并急性尿潴留患者尿动力学及PSA水平的影响 被引量:5

Clinical Observation of Tonglin Decoction Combined with Tamsulosin on Urodynamics and PSA Levels in Advanced Prostate Cancer Patients with Acute Urinary Retention
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摘要 目的探讨通淋汤联合坦索罗辛对高龄晚期前列腺癌并急性尿潴留患者尿动力学及PSA水平的影响。方法以80例高龄晚期前列腺癌并急性尿潴留患者为研究对象,随机分为对照组与观察组各40例,对照组予坦索罗辛口服,观察组在对照组基础上服用通淋汤。比较两组保守治疗有效率,保守治疗有效患者尿动力学及PSA水平。结果对照组保守治疗有效者31例,有效率为77.50%,观察组保守治疗有效者37例,有效率为92.50%,观察组保守治疗有效率高于对照组(P<0.05)。观察组保守治疗有效患者留置导尿平均时间、24 h排尿次数低于对照组,而单次排尿尿量高于对照组(P<0.05)。治疗后,观察组IPSS及QOL评分显著优于对照组(P<0.05),观察组MER及RU指标改善显著优于对照组(P<0.05),观察组血清PSA水平低于对照组,但差异无统计学意义(P>0.05)。结论通淋汤联合坦索罗辛可有效调节晚期高龄前列腺癌并急性尿潴留患者血清PSA水平,改善其尿动力学指标,减轻患者排尿困难及腹胀腹痛等症状。 Objective:To investigate the effect of Tonglin Decoction combined with tamsulosin on urodynamics and PSA level in advanced prostate cancer patients with acute urinary retention.Methods:A total of 80 patients with advanced prostate cancer and acute urinary retention in our hospital were selected and randomly divided into the control group and observation group,40 cases in each group.The control group was given tamsulosin orally,and the observation group was given Tonglin Decoction on the basis of the control group.The efficacy,urodynamics and PSA levels of the two groups were compared.Results:1)There were 31 patients in the control group who were effective with conservative treatment,with an effective rate of 77.50%,and 37 cases in the observation group,with an effective rate of 92.50%,the effective rate of conservative treatment in the observation group was higher than that of the control group(P<0.05);the average time and frequency of 24-hour urination in the observation group were lower than those in the control group,and the single urination volume was higher than that of the control group(P<0.05).2)After treatment,the IPSS and QOL scores of the observation group were significantly better than those of the control group(P<0.05),the MER and RU indexes of the observation group were significantly better than those of the control group(P<0.05),and the serum PSA level of the observation group was better than that of the control group,but the difference was not statistically significant(P>0.05).Conclusion:Tonglin Decoction combined with tamsulosin can effectively regulate serum PSA level in advanced prostate cancer patients with acute urinary retention,improve their urodynamic indicators,and relieve dyuria and abdominal distention and pain.
作者 楚晨龙 徐继国 陈春雷 黄天润 刘建河 Chu Chenlong;Xu Jiguo;Chen Chunlei;Huang Tianrun;Liu Jianhe(Shanghai Hospital of Traditional Chinese Medicine,Shanghai 200071,China)
机构地区 上海市中医医院
出处 《中国中医急症》 2023年第3期471-474,共4页 Journal of Emergency in Traditional Chinese Medicine
基金 上海中医药大学产业发展中心医养结合科创项目(YYKC-2021-01-143)。
关键词 晚期前列腺癌 急性尿潴留 高龄 通淋汤 坦索罗辛 尿动力学 Advanced prostate cancer Acute urinary retention Advanced age Tonglin Decoction Tamsulosin Urine dynamics
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