探讨头孢哌酮钠舒巴坦钠在治疗老年中重度细菌性肺炎中的有效性及对实验室指标的影响

Exploring the Effectiveness of Cefoperazone Sodium Sulbactam in the Treatment of Moderate-to-severe Bacterial Pneumonia in the Elderly and the Effect on Laboratory Indices

目的 分析头孢哌酮钠舒巴坦钠在治疗老年中重度细菌性肺炎(bacterial pneumonia, BP)中的临床疗效以及对实验室指标的影响。方法 随机选取2021年1—12月在首都医科大学石景山教学医院住院的70例老年中重度BP患者为研究对象,根据抽签法分组,每组35例。对比组接受可乐必妥治疗,研究组接受头孢哌酮钠舒巴坦钠治疗。对比两组临床疗效、临床指标、血清炎症指标、肺功能指标、不良反应总发生率。结果研究组临床总有效率(94.29%)高于对比组(71.43%),差异有统计学意义(χ^(2)=6.437,P=0.011)。研究组咳嗽消失、细菌转阴、体温复常、肺部征象消失、住院时间均短于对比组,差异有统计学意义(P<0.05)。治疗后,研究组血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)均低于对比组,差异有统计学意义(P<0.05)。研究组治疗后第1秒用力呼气量(FEV_1)、潮气量(V-T)均高于对比组,差异有统计学意义(P<0.05)。两组不良反应总发生率(2.86%vs 8.57%)比较,差异无统计学意义(P>0.05)。结论 头孢哌酮钠舒巴坦钠可有效改善老年中重度BP患者肺功能,促进炎症病灶吸收,且不良反应较少。

Objective To analyze the clinical efficacy of cefoperazone sodium sulbactam in the treatment of moderate-to-severe bacterial pneumonia(BP)in the elderly and the effect on laboratory indices.Methods Seventy elderly pa⁃tients with moderate-to-severe BP hospitalized in Shijingshan Teaching Hospital of Capital Medical University from January to December 2021 were randomly selected for the study and were grouped according to the lottery method,35 with cases in each group.The comparison group received colestipol treatment and the study group received cefopera⁃zone sodium sulbactam sodium treatment.The clinical efficacy,clinical indexes,serum inflammation indexes,pulmo⁃nary function indexes,and the total incidence of adverse reactions were compared between the two groups.Results The total clinical efficiency of the study group(94.29%)was higher than that of the comparison group(71.43%),and the difference was statistically significant(χ^(2)=6.437,P=0.011).The disappearance of cough,bacterial conversion,tem⁃perature normalization,disappearance of pulmonary signs and hospitalization time in the study group were shorter than those in the comparison group,and the difference was statistically significant(P<0.05).After treatment,serum C-reactive protein(CRP),interleukin-6(IL-6)and calcitoninogen(PCT)in the study group were lower than those in the comparison group,and the differences were statistically significant(P<0.05).The first second forceful expiratory vol⁃ume(FEV 1)and tidal volume(V-T)after treatment in the study group were higher than those in the comparison group,