某院ICU 111例药品不良反应报告分析

Analysis of 111 cases of adverse drug reactions in ICU of our hospital

目的回顾性分析2017~2021年ICU的药品不良反应发生情况,以期更好的控制药品风险。方法从医疗安全(不良)事件报告系统中提取2017~2021年来源于ICU的药品不良反应报告共111例,对患者的年龄、涉及药物分类、给药途径、不良反应累及系统-器官、严重程度及转归等进行统计分析。结果60岁以上患者占比为66.67%;静脉滴注给药途径占比75.68%;涉及的药物种类中占比最高的是抗感染药物(59.46%);累及系统-器官最多的是皮肤及其附件损害(21.62%);一般药品不良反应占比为75.68%,其中97.62%好转,严重药品不良反应占比24.32%,其中81.48%好转。结论ICU药品不良反应严重程度以一般为主,在ICU药品不良反应监测过程中,60岁以上患者为重点人群,静脉滴注为重点监测给药途径,抗感染药物为重点监测药物,皮肤及其附件损害是提示药品不良反应发生的重要信号。

Objective The occurrence of adverse drug reactions in ICU of our hospital from 2017 to 2021 was retrospectively analyzed in order to better control drug risks.Methods A total of 111 ADR reports in ICU from 2017 to 2021 were extracted from the medical safety(adverse)event reporting system of our hospital.The age,drug classification,route of administration,organs/systems involved in adverse reactions,severity and outcome of patients were statistically analyzed.Results Patients over 60 years old accounted for 66.67%;Intravenous drip accounted for 75.68%;The highest proportion of drugs involved was anti infective drugs(59.46%);The most involved organs/systems were skin and its accessories(21.62%);General adverse drug reactions accounted for 75.68%,of which 97.62%improved,and serious adverse drug reactions accounted for 24.32%,of which 81.48%improved.Conclusion The severity of adverse drug reactions in ICU is mainly general.Patients over 60 years old are the key population,intravenous drip is the key monitoring route of administration,anti infective drugs are the key monitoring drugs,and the damage of skin and its accessories is an important signal to indicate the occurrence of adverse drug reactions.