肺部超声对激素治疗BPD的疗效评价研究

Evaluation of the effect of pulmonary ultrasound on hormone therapy of BPD

目的:探究肺部超声对激素治疗支气管肺发育不良(broncho-pulmonary dysplasia,BPD)患儿的疗效。方法:选取2021年1月—2022年12月济南市第二妇幼保健院收治的60例BPD患儿,其中应用激素(DART方案)治疗的30例纳入观察组,同期30例BPD患儿未使用激素治疗作为对照组,给予0.9%氯化钠溶液治疗。比较两组患儿的临床效果及不良反应发生情况,观察并记录接受激素患者在治疗前、治疗4 d、治疗10 d的肺部评分、氧合指数。结果:观察组患儿的住院时间、用氧时间、呼吸支持时间短于对照组,差异均有统计学意义(P<0.05);观察组患儿的不良反应总发生率为3.33%,低于对照组的26.67%,两组差异有统计学意义(P<0.05)。治疗前、治疗4 d、治疗10 d,超声评分呈现明显降低趋势,OI水平呈现明显增高趋势,不同时点的超声评分、OI水平差异具有统计学意义(P<0.05)。结论:激素对BPD患儿的治疗有效,可缩短呼吸支持时间、用氧时间与住院时间,不良反应少,且肺部超声评分与氧合指数应用于激素治疗BPD患儿的疗效评价中可取得相当的效果,临床更推荐应用超声评分评估疗效。

Objective To explore the effect of pulmonary ultrasound on hormone therapy in children with broncho-pulmonary dysplasia(BPD).Methods 60 children with BPD admitted to Jinan Second Maternal and Child Health Hospital from January 2021 to December 2022 were included in this study,30 of whom were treated with hormone(DART protocol)were included in the observation group,and 30 children with BPD were not treated with 0.9%sodium chloride solution at the same time as the control group,and were treated with normal saline.The clinical effects and adverse reactions of the two groups were compared,and the lung score and oxygenation index of patients receiving hormone before treatment,4 days after treatment and 10 days after treatment were observed and recorded.Results The hospitalization time,oxygen use time and respiratory support time of children in the observation group were shorter than those in the control group,the difference was statistically significant(P<0.05);The total incidence of adverse reactions in the observation group was 3.33%,which was lower than 26.67%in the control group,the difference between the two groups was statistically significant(P<0.05).Before treatment,4 days after treatment,and 10 days after treatment,the ultrasound score showed a significant downward trend,and the OI level showed a significant upward trend.The ultrasound score and OI level at different time points were statistically significant(P<0.05).Conclusion Hormone is effective in the treatment of children with BPD,which can shorten the time of respiratory support,oxygen use and hospitalization,and has fewer adverse reactions.In addition,the application of lung ultrasound score and oxygenation index in the evaluation of the curative effect of hormone treatment of children with BPD can achieve considerable results.It is more recommended to use ultrasound score in clinical evaluation of the curative effect.