肠道屏障在肥胖相关代谢性疾病发生发展中的作用

Role of intestinal barrier in the occurrence and development of obesity related metabolic diseases

随着肥胖人口所占比例增加,非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)和2型糖尿病(type 2 diabetes mellitus,T2DM)等肥胖相关代谢性疾病发病率逐年上升,给家庭及社会带来沉重负担。大量实验数据证实肠道屏障损伤在肥胖相关代谢性疾病的发生发展过程中起重要作用。本文详细总结了肠道屏障的结构、功能及评估方法,归纳了肠道屏障损伤与肥胖及其相关代谢性疾病的研究进展,为临床如何评估患者肠道屏障功能以及如何通过改善肠道屏障功能治疗代谢性疾病提供理论基础。

With the increase of the proportion of obese population,the incidence of obesity related metabolic diseases such as nonalcoholic fatty liver disease(NAFLD) and type 2 diabetes mellitus(T2DM) is increasing year by year,which brings a heavy burden to the family and society.A large number of experimental data confirm that intestinal barrier injury plays an important role in the occurrence and development of obesity related metabolic diseases.This paper summarizes the structure,function and evaluation methods of intestinal barrier in detail,and summarizes the research progress of intestinal barrier injury and obesity related metabolic diseases,so as to provide a theoretical basis for how to evaluate patients’ intestinal barrier function and how to treat metabolic diseases by improving intestinal barrier function.