孕妇血型不规则抗体检测对预防新生儿溶血病的作用

Effect of Antibody Detection of Irregular Blood Group in Pregnant Women on Prevention of Hemolytic Disease in Newborn

目的探讨孕妇进行血型不规则抗体检测用于新生儿溶血病的预防作用。方法选取2017年1月—2021年12月连云港市妇幼保健院接受不规则抗体检测的门诊及住院孕妇30名作为观察组,选择同期孕妇与配偶血型不合但未接受不规则抗体检测的孕妇30名作为对照组,对比两组新生儿溶血病发生率,分析观察组孕妇不同的抗体效价的新生儿溶血病发病率。结果观察组新生儿溶血病的发生率(6.67%)明显低于对照组,差异有统计学意义(χ^(2)=13.871,P<0.05)。抗体效价≥1∶256的孕妇发生新生儿溶血病的概率高达100.00%。结论针对与配偶血型不合的孕妇,应开展血清不规则抗体检测工作,便于及时发现母婴血型不合情况,预防新生儿溶血病,保障母婴安全。

Objective To investigate the preventive effect of blood types irregular antibody detection in pregnant women on hemolytic disease of newborn.Methods 30 out-patient and inpatient pregnant women who received irregu⁃lar antibody detection in Lianyungang Maternal and Child Health Care Hospital from January 2017 to December 2021 were selected as the observation group.30 pregnant women with incompatible blood type with their spouses who did not receive irregular antibody detection were selected as control group.The incidence of hemolytic disease was com⁃pared between the two groups.The analysis of the different antibody titers of pregnant women in the observation group.Results The probability of hemolytic disease in the observation group was 6.67%,which was lower than that in the control group,the difference was statistically significant(χ^(2)=13.871,P<0.05).The probability of neonatal hemolytic disease in pregnant women with antibody titer≥1∶256 was as high as 100.00%.Conclusion For pregnant women with blood type incompatibility with their spouses,irregular serum antibody detection should be carried out to facilitate timely detection of maternal and infant blood type incompatibility,prevention of neonatal hemolytic disease,protection of maternal and infant safety.