益生菌联合草酸艾司西酞普兰对抑郁发作患者的疗效评价

Efficacy Evaluation of Probiotics Combined with Escitalopram Oxalate in Patients with Depressive Episode

目的探究益生菌联合草酸艾司西酞普兰对抑郁发作患者的治疗效果。方法选择2020年7月—2021年10月内蒙古包头市第六医院就诊的80例抑郁发作患者为研究对象,随机分为研究组和对照组,每组40例。对照组给予草酸艾司西酞普兰治疗,研究组在对照组基础上联合应用益生菌治疗。对比两组患者的焦虑抑郁情况、炎症因子及外周血T淋巴细胞比例。结果治疗后,研究组HAMD评分(5.667±1.740)分、HAMA评分(1.917±0.967)均分低于对照组(6.686±2.166)分、(4.229±1.003)分,差异有统计学意义(t=2.188、4.334,P<0.05)。治疗后,研究组IL-6、TNF-α水平均低于对照组,CD3^(+)T、CD4^(+)T、CD4^(+)T/CD8^(+)T均高于对照组,CD8^(+)T低于对照组,差异有统计学意义(P<0.05)。结论益生菌联合草酸艾司西酞普兰治疗抑郁发作患者疗效明显,可降低焦虑抑郁程度,减少炎症反应,调节T淋巴细胞群,提高免疫功能,促进病情康复。

Objective To explore the therapeutic effect of probiotics combined with escitalopram oxalate on patients with depressive episode.Methods 80 patients with depressive episode who visited Baotou Sixth Hospital from July 2020 to October 2021 were selected as subjects.They were randomly divided into study group and control group,with 40 cases in each group.The control group was treated with escitalopram,while the study group was treated with Esci⁃talopram Oxalate on the basis of the control group.Anxiety and depression,inflammatory factors and peripheral blood T lymphocyte ratio were compared between the two groups.Results After treatment,HAMD scores(5.667±1.740)points and HAMA scores(1.917±0.967)points of the study group were lower than those of the control group(6.686±2.166)points and(4.229±1.003)points,the difference was statistically significant(t=2.188,4.334,P<0.05).After treatment,the levels of IL-6 and TNF-αin the study group were lower than those in the control group,CD3^(+)T,CD4^(+)T,CD4^(+)T/CD8^(+)T were higher than those in the control group,CD8^(+)T was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Probiotics combined with escitalopram oxalate have obvi⁃ous curative effect in the treatment of patients with depressive episode,which can reduce anxiety and depression,re⁃duce inflammatory response,regulate T lymphocyte population,improve immune function and promote rehabilitation of the disease.