晚期膝关节骨性关节炎病人血清尿酸水平与性别和年龄的关系

ASSOCIATION OF SERUM URIC ACID LEVEL WITH SEX AND AGE IN PATIENTS WITH ADVANCED KNEE OSTEOARTHRITIS

目的探讨晚期膝关节骨性关节炎(KOA)病人血清尿酸水平与性别、年龄的关系。方法以2020年于青岛大学附属医院骨科中心行全膝关节置换手术的1484例KOA病人作为研究对象(男372例,女1112例;年龄40~89岁,平均(66.76±6.52)岁),记录其术前空腹12 h的血清尿酸值,分析不同年龄、性别病人血清尿酸水平的差异。结果女性病人人数约为男性病人的3倍。男性病人血清尿酸水平显著高于女性病人(t=9.705,P<0.05)。50~79岁女性病人占女性晚期KOA病人总数的96.58%,其中以60~69岁年龄段人数占比最高。50~59岁、60~69岁、70~79岁3个年龄段女性病人的血清尿酸水平与40~49岁年龄段病人相比均明显增高,差异具有统计学意义(F=4.553,q=4.597~5.116,P<0.05)。男性病人也以60~69岁年龄段人数占比最高,但各年龄段病人血清尿酸水平变化不明显,且有随年龄增长下降的趋势。结论在女性晚期KOA病人中,患病人数占比较高年龄段的病人血清尿酸水平显著升高,血清尿酸水平可能与女性晚期KOA有关。

Objective To investigate the association of serum uric acid(UA)level with sex and age in patients with advanced knee osteoarthritis(KOA).Methods A total of 1484 patients with KOA who received total knee arthroplasty in Orthopaedic Center of The Affiliated Hospital of Qingdao University in 2020 were enrolled as subjects,among whom there were 372 male patients and 1112 female patients,aged 40-89 years(mean age:66.76±6.52 years).Serum UA level was recorded after 12 hours of fasting before surgery and was compared between the patients with different ages and sexes.Results The number of the female patients was about three times that of the male patients.The male patients had a significantly higher serum UA level than the female patients(t=9.705,P<0.05).The female patients aged 50-79 years accounted for 96.58%of the female patients with advanced KOA,among whom the patients aged 60-69 years accounted for the highest proportion.The female patients aged 50-59,60-69,and 70-79 years had a significantly higher serum UA level than those aged 40-49 years(F=4.553,q=4.597-5.116,P<0.05).As for the male patients,those aged 60-69 years accounted for the highest proportion;there was no significant difference in serum UA level between the patients of different ages,and serum UA level tended to decrease with age.Conclusion Among female patients with advanced KOA,the age group accounting for a high proportion has a significant increase in serum UA level,suggesting that serum UA level may be associated with advanced KOA in female patients.